PMID: 9165415Jun 1, 1997Paper

Changes in the lung after prolonged positive pressure ventilation in normal baboons

Journal of Critical Care
S G SimonsonC A Piantadosi

Abstract

The effects of prolonged positive pressure ventilation on lung ultrastructure are not well defined in primates. This study was designed to measure cardiopulmonary and morphological responses to 4 days of positive pressure ventilation in normal baboons. Six adult male baboons were mechanically ventilated on air for 96 hours with 2.5 cm positive end-expiratory ventilation and a tidal volume of 12 to 15 mL/kg. Physiological measurements were obtained every 12 hours and serial measurements of ventilation-perfusion (VA/Q) were performed using the multiple inert gas elimination technique. Quantitative morphotometry, lung dry-to-wet ratio, and surfactant analysis were performed at the end of the experiment. Cardiovascular variables, except for a small increase in mean pulmonary artery pressure at 84 and 96 hours, were not significantly affected by positive pressure ventilation. Arterial Po2 decreased, and shunt fraction increased from 0.7% of cardiac output to 5.4% (P < .01). Dispersion of perfusion increased threefold (P < .01), and dispersion of ventilation doubled (P < .01) indicating increased VA/Q mismatch mismatch. Respiratory system compliance decreased by 30% (P < .01). There was no lung edema or change in surfactant compositi...Continue Reading

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Citations

Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·M S CarrawayC A Piantadosi
Apr 18, 2006·Journal of Critical Care·Dan TorbatiBalagangadhar R Totapally
Apr 9, 2008·Seminars in Thoracic and Cardiovascular Surgery·Bernard J Park
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Aug 7, 2010·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Jaeyeun KimChongyon Park
Aug 16, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Karen E Welty-WolfClaude A Piantadosi
Oct 11, 2005·European Journal of Anaesthesiology·B WalderD R Morel
Dec 1, 2001·Pediatric Research·A L LinesS B Hooper
Aug 13, 1999·The American Journal of Physiology·J SavovS L Young

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