Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study

Experimental Biology and Medicine
Syed Z ImamM G Paule

Abstract

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration. Overall changes in metabolites and microRNAs were observed in biological fluids that were associated with neurotoxic damage induced by trimethyl tin. Behavioral changes and magnetic resonance imaging T2 relaxation and ventricle volume changes served to identify animals that responded to the adverse effects of trimethyl tin. Impact statement These data will help design follow-on studies with other known neurotoxicants to be used to assess the broad applicability of the present findings. Together this approach rep...Continue Reading

References

Apr 29, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiJ S Wolinsky
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Mar 21, 2009·Amino Acids·Guoyao Wu
Sep 2, 2009·Progress in Lipid Research·Lauren L JonesPeggy R Borum
Mar 9, 2011·Progress in Lipid Research·Martin HermanssonPentti Somerharju
Oct 8, 2011·Biochimica Et Biophysica Acta·Laura K ColeDennis E Vance
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
Sep 1, 2011·Expert Opinion on Medical Diagnostics·Janet WoodcockIssam Zineh
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Winston KohStephen R Quake
May 17, 2014·Nature Reviews. Drug Discovery·David CookMenelas N Pangalos
Sep 30, 2014·Regulatory Toxicology and Pharmacology : RTP·Joseph HanigSerguei Liachenko
Dec 17, 2014·Toxicology and Applied Pharmacology·Virginia C MoserDavid W Herr
Apr 24, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Serguei LiachenkoJoseph Hanig
Nov 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ruth A RobertsMerle G Paule
Feb 28, 2016·Nucleic Acids Research·Nicole LudwigAndreas Keller
Aug 19, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Su-Eon SimBong-Kiun Kaang
Oct 11, 2016·Journal of Experimental Neuroscience·Balachandar Radhakrishnan, A Alwin Prem Anand
Apr 19, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mariah L HoyeTimothy M Miller
Jul 12, 2017·Expert Opinion on Drug Safety·Vincenzo FodaleAntonio David
Sep 18, 2017·Critical Reviews in Oncology/hematology·Milena VitaliGiuseppe Lo Russo

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Citations

Sep 27, 2018·Experimental Biology and Medicine·Abigail L WalkerRuth A Roberts
Apr 27, 2019·Metabolites·Víctor González-RuizSerge Rudaz
Apr 22, 2021·International Journal of Toxicology·Anshul SrivastavaJoseph P Hanig
Sep 8, 2018·The Science of the Total Environment·Renato RussoMatthias Liess
Oct 23, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tomoya SanoMasaaki Kakehi

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Methods Mentioned

BETA
PCR

Software Mentioned

Biocrates MetIDQ (
AB Sciex Analyst

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