PMID: 9533645Apr 9, 1998Paper

Changes in the microstructure of feeding after administration of enterostatin into the paraventricular nucleus and the amygdala

Peptides
L Lin, D A York

Abstract

The effects of enterostatin (ENT) injected into the paraventricular nucleus (PVN) and the amygdala (AMYG) on the microstructure of feeding was studied by using an automated feeding apparatus. In rats adapted to a 6-h meal feeding regime, ENT reduced the size and duration of the first meal after injection in both the PVN and the AMYG. Similar effects were observed when ENT was given at the beginning of the dark cycle in rats fed ad libitum although the onset of feeding was also delayed in this situation. The number of meals and the size of subsequent meals was unaffected by ENT but the eating rate within the first meal was reduced after ENT injection into the AMYG of meal-fed rats. Enterostatin injected into the AMYG at a dose that suppressed feeding did not produce a conditioned taste aversion. ENT given centrally therefore appears to reduce food intake by delaying the initiation of feeding and/or advancing meal termination suggesting that it affects both appetite and satiation mechanisms.

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Citations

Apr 24, 2001·Pharmacology & Therapeutics·J C ClaphamM Tadayyon
Aug 26, 2000·Current Opinion in Chemical Biology·L H Van der Ploeg
Dec 13, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ling LinDavid A York
Jan 24, 2006·Peptides·Stefany D PrimeauxGeorge A Bray
Nov 28, 2012·Neuroscience Letters·H Jonaidi, R Rasooli
Jul 10, 2002·Obesity Research·Jie MeiCharlotte Erlanson-Albertsson
Dec 2, 2004·Peptides·Miejung ParkDavid A York
Dec 7, 2007·Biotechnology & Genetic Engineering Reviews·Kai HilperRobert E W Hancock
Jun 21, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael M Chi, Terry L Powley
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ling LinDavid A York

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