PMID: 6159372Sep 1, 1980Paper

Changes in the molecular size distribution and post-transfusion survival of hydroxyethyl starch 350/0.60 as influenced by a lower degree of hydroxyethylation: a study in normal man

Journal of Clinical Pathology
J M MishlerE J Parkhouse

Abstract

The need to provide a greater rate of colloid clearance from blood than is presently available with the long-acting dosage form of HES 450/0.70 prompted the clinical investigation of a new species of hydroxyethyl starch (HES) possessing a M-w of 350000 concomitant with a molar substitution of 0.60 (HES 350/0.60). The concentration of HES 350/0.60 in serum fell to half its peak value in 10.2 +/- 0.7 (SD) hour (in contrast to an IT50 of approximately 25 hours with HES 450/0.70). Levels of glucose in serum remained elevated in normal fasted subjects after dosing, suggesting that catabolism of the infused HES 350/0.60 was occurring. Hydrolysis of residual HES 350/0.60 was confirmed by Sepharose CL-4B gel filtration analysis of material obtained from serum, showing continual production of smaller molecules relative to the injected solution (in contrast to HES 450/0.70, in which intermediate polymer fragments are recovered). Recovered HES 350/0.60 material displayed a Kav ranging between 0.74 and 0.72 and possessed a Stokes radius (r = 45A) similar to that of dextran 40 (M-w 41000). HES 350/0.69 appears to offer the same advantages as the currently available long-acting HES 450/0.70 but is removed from blood approximately twice as ra...Continue Reading

References

Jan 1, 1976·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J C BoonK Messmer
Oct 1, 1977·The Journal of Surgical Research·J M MishlerR Gross
May 1, 1979·British Journal of Clinical Pharmacology·J M MishlerE J Parkhouse
Nov 1, 1976·Transfusion·R M LowenthalJ M Goldman
Apr 1, 1970·British Journal of Pharmacology·S P FarrowC R Ricketts
May 1, 1967·Journal of Chromatography·K A Granath, B E Kvist
Feb 1, 1980·Journal of Clinical Pathology·J M MishlerE J Parkhouse
Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·G ARTURSON, G WALLENIUS

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Citations

Jan 1, 1983·Journal of Clinical Apheresis·J M MishlerR G Strauss

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