PMID: 9535113Apr 16, 1998Paper

Changes in the morphology of sympathetic preganglionic neurons parallel the development of autonomic dysreflexia after spinal cord injury in rats

Neuroscience Letters
N R Krenz, L C Weaver

Abstract

Following spinal cord transection (SCT), sensory input to the spinal cord causes increases in arterial pressure that are small in rats 1 week after SCT, but become large and well established by 2 weeks. Moreover, sympathetic preganglionic neurons (SPNs) undergo atrophy by 1 week after SCT, and regeneration of these neurons may be an important factor in the etiology of this autonomic dysreflexia. Therefore, we examined the morphology of SPNs 2 weeks after SCT using retrograde transport of the cholera toxin subunit B. The dendritic arbors of SPNs were re-established by 2 weeks after SCT. This regeneration parallels the time course of the development of autonomic dysreflexia after cord injury in the rat, and may play a role in initiating this disorder.

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Citations

Mar 9, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexander G Rabchevsky, Patrick H Kitzman
Dec 12, 2001·Neuroscience·J E JacobA Brown
Dec 12, 2012·Journal of Neurotrauma·Megan Ryan DetloffJohn D Houlé
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R ZahnerLawrence P Schramm
Jan 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R Zahner, Lawrence P Schramm
Apr 17, 2013·Spinal Cord·P ProficeV Di Lazzaro
Jul 3, 2010·Autonomic Neuroscience : Basic & Clinical·Tomas KalincikPhil M E Waite
Jun 16, 2009·Journal of Chemical Neuroanatomy·Ida J Llewellyn-Smith
May 12, 2000·Hematology/oncology Clinics of North America·A R Miranda, H I Hassouna
Aug 26, 2014·Respiratory Physiology & Neurobiology·Philippa M WarrenWarren J Alilain
Oct 13, 2016·Neuroscience Bulletin·Ying WangLing-Xiao Deng
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A S LairdP Carrive
Jun 8, 2001·The Journal of Comparative Neurology·I J Llewellyn-Smith, L C Weaver
Nov 26, 2003·Anesthesiology·Laura L YangMerlin D Larson
Nov 30, 2019·Frontiers in Cellular Neuroscience·Felicia M MichaelAlexander G Rabchevsky
Aug 15, 2020·Frontiers in Cellular Neuroscience·Micaela L O'Reilly, Veronica J Tom
Nov 2, 2017·Neural Regeneration Research·Hisham Sharif, Shaoping Hou

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