Changes in the mucoadhesion of powder formulations after drug application investigated with a simplified method

Journal of Pharmaceutical Sciences
Nelly FransénKatarina Edsman

Abstract

The residence time in the nasal cavity can be prolonged by dry particles that absorb water and subsequently increase the viscosity of the mucus layer. A novel nasal drug delivery system based on interactive mixtures has previously been developed, where fine particles of the active component are adhered to the surface of mucoadhesive carrier particles by dry mixing. The surface coverage may alter the original mucoadhesiveness of the carrier particles and to investigate this, a simplified tensile strength method was developed and evaluated. Reliable results were obtained with a plastic coated absorbent paper covered by a mucin solution as a substitution for porcine nasal mucosa and should also be applicable to other dry particle systems. The method showed that the swelling of sodium starch glycolate particles was slightly delayed, corresponding to the degree of hydrophobic surface coverage. Carrier particles of partly pregelatinized maize starch were not influenced by the addition of a hydrophobic substance, probably because of the rough particle shape that inhibited a complete surface coverage. It was concluded that the surface coverage of carrier particles in interactive mixtures only could cause a short delay in water absorpti...Continue Reading

References

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Apr 25, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nelly FransénChrister Nyström

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Citations

Mar 20, 2009·Pharmaceutical Research·Nelly FransénErik Björk
Jan 26, 2010·Expert Opinion on Drug Delivery·Maya Davidovich-Pinhas, Havazelet Bianco-Peled
Apr 1, 2011·Journal of Pharmaceutical Sciences·Elisabetta GaviniAlessandro Dalpiaz
Dec 5, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Flávia Chiva CarvalhoMaria Palmira Daflon Gremião
Apr 5, 2011·International Journal of Pharmaceutics·Swati PundChamanlal Shishoo
Aug 3, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bence SiposGábor Katona

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