Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitrite

Bioscience, Biotechnology, and Biochemistry
Shuichi MasudaNaohide Kinae

Abstract

We determined the changes in the mutagenic and estrogenic activities of 17beta-estradiol after a nitrite treatment. Nitrite-treated 17beta-estradiol showed mutagenic activities toward Salmonella typhimurium strains TA 100 and TA 98. We confirmed that nitrite-treated 17beta-estradiol generated radicals from the results of an analysis of electron spin resonance. By applying an instrumental analysis, we identified 2-nitro-17beta-estradiol to have been formed in the reaction mixture. 2-Nitro-17beta-estradiol did not exhibit mutagenic activities toward Salmonella typhimurium strains, suggesting that other mutagens might have been formed in the reaction mixture. The clastogenic properties of nitrite-treated 17beta-estradiol and 2-nitro-17beta-estradiol were analyzed by a micronucleus test with male ICR mice. Nitrite-treated 17beta-estradiol and 2-nitro-17beta-estradiol induced a significantly higher frequency of micronucleated reticulocytes in mice. The estrogenic activity of 2-nitro-17beta-estradiol was found to be lower than that of 17beta-estradiol. These data suggest that a daily oral intake of 17beta-estradiol and nitrite might induce the formation of mutagenic compounds in our body.

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Citations

Jun 29, 2012·Bioscience, Biotechnology, and Biochemistry·Shuichi MasudaNaohide Kinae
Aug 8, 2008·Bioscience, Biotechnology, and Biochemistry·Tomoyasu ToyoizumiNaohide Kinae
Sep 25, 2009·Water Environment Research : a Research Publication of the Water Environment Federation·Linda S GaulkeH David Stensel
Oct 8, 2009·Environmental Science & Technology·Linda S GaulkeH David Stensel

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