Abstract
One group of mice was injected subcutaneously with 20 mg/kg body wt isoprenaline each day for 10 days; another group (control) was injected with saline. Half the animals of each group were kept untreated for a further 10 days for restoration. Chronic administration of isoprenaline caused enlargement of parotid (4-fold) and submandibular glands (1.7-fold) but had no effect on sublingual glands. Concomitantly, noradrenaline and acetylcholine contents were, in parallel, increased in parotid, decreased in sublingual, and unchanged in submandibular glands. Under these conditions, pilocarpine- or isoprenaline-induced salivation was not affected but phenylephrine-induced salivation was augmented; the protein component patterns of saliva characteristic of the three sialogogues were also changed. In addition, secretory proteins whose synthesis was induced by isoprenaline were found to be secreted by stimulation with different types of sialogogues. Most changes were reversible. These results indicate that continued beta-adrenoceptor stimulation not only causes broadly altered forms of saliva, probably by involving, in part, alpha-adrenoceptor hypersensitivity, but also changes the activities of both sympathetic and parasympathetic nerves...Continue Reading
References
Mar 11, 1977·Brain Research·M D DibnerI B Black
Mar 1, 1977·Journal of Dental Research·M R RobinovitchD L Kauffman
Jan 1, 1992·Mechanisms of Ageing and Development·S LahtivirtaA Hervonen
Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·H SaitoT Itoh
Jul 1, 1989·Journal of Pharmacological Methods·S MuraiT Itoh
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·G B ProctorJ R Garrett
Jan 1, 1985·The Journal of Physiology·C J Jones, S M Wilson
Oct 1, 1985·Journal of the Autonomic Nervous System·C A Schneyer
Feb 1, 1987·Journal of Dental Research·J R Garrett
Oct 1, 1987·Biochimica Et Biophysica Acta·R O López-SolísD Miranda
May 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·H D Hall, C A Schneyer
Sep 1, 1972·Developmental Biology·T EkforsT Barka
Aug 15, 1970·Nature·U K Laemmli
Dec 1, 1982·Journal of Dental Research·K Abe, C Dawes
Jan 15, 1982·Analytical Biochemistry·G Dubray, G Bezard
May 1, 1982·Journal of Dental Research·D A Johnson, L M Sreebny
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H MehanshoD M Carlson
Jun 1, 1980·Journal of Dental Research·K Abe, C Dawes
Mar 9, 1981·Brain Research·H DietlA Philippu
Jul 1, 1995·Archives of Oral Biology·S MuraiT Itoh
Oct 1, 1995·Archives of Oral Biology·S S SchwartzL M Sreebny
Jan 6, 1961·Science·H SELYEM CANTIN
Aug 1, 1962·The American Journal of Physiology·C A SCHNEYER
Aug 1, 1964·The American Journal of Physiology·H WELLS, A A PERONACE
May 1, 1965·The American Journal of Physiology·H WELLSL W STARK
Citations
May 7, 1998·Archives of Oral Biology·S MuraiT Kawaguchi
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Wilson Abrão SaadSylvio Simões
Mar 15, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·T KawaguchiH Saito
Jan 27, 2009·Micron : the International Research and Review Journal for Microscopy·A C IssyE A Del Bel
May 18, 2004·The Journal of Physiology·Takeshi NakamuraKatsuhiko Mikoshiba
Dec 23, 2009·Biochimica Et Biophysica Acta·David A Brown, David I Yule
May 15, 2015·Acta Oto-laryngologica·Ai KawamotoYukio Katori
Mar 23, 2001·Archives of Physiology and Biochemistry·J NicolauG Nunez-Burgos
May 1, 2021·Biology·Masanobu Yoshikawa, Mitsuru Kawaguchi