PMID: 8947496Nov 15, 1996Paper

Changes in the nuclear matrix of chicken erythrocytes that accompany maturation

The Biochemical Journal
H Y ChenJ R Davie

Abstract

The protein composition and structure of nuclear matrices isolated from adult chicken immature and mature erythrocytes were analysed. Visualization of nuclear matrices by electron microscopy showed that immature-erythrocyte nuclear matrices had internal structures, while most mature-erythrocyte nuclear matrices did not. Both mature- and immature-erythrocyte nuclear matrices were surrounded by a fibrous network of intermediate filaments. Two-dimensional gel electrophoretic analysis of proteins obtained from fractionated nuclear matrices led to the assignment of the proteins as components of the nuclear porelamina, internal matrix, or cytoskeleton. Common and different proteins belonging to one of the three groups were identified in nuclear matrices of immature and mature erythrocytes. Investigation of the partitioning of histone deacetylase activity, an enzyme associated with the internal matrix, among the erythroid nuclear matrix fractions provided evidence that mature- and immature-erythrocyte nuclear matrices have internal structures. However, the activity of histone deacetylase and level of internal matrix proteins from mature-erythrocyte nuclear matrices were less than those from immature-erythrocyte matrices. The low level...Continue Reading

Citations

Dec 2, 1999·Experimental Cell Research·G S SteinS M Pockwinse
Oct 24, 2006·PLoS Computational Biology·Kirk J McManusMichael J Hendzel
Jul 30, 2011·Journal of Biosciences·Parul Varma, Rakesh K Mishra
Jun 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G S SteinS McNeil
Sep 11, 2007·The Journal of Biological Chemistry·Jian-Min SunJames R Davie
Jan 1, 1998·Journal of Cellular Biochemistry·Gary S SteinSandra McNeil
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ZengG S Stein

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