PMID: 6989406Mar 20, 1980Paper

Changes in the number of insulin receptors of isolated rat hepatocytes during pregnancy and lactation

Biochimica Et Biophysica Acta
D J Flint

Abstract

The weight of the rat liver increased during pregnancy and lactation due solely to an increase in hepatocyte size. Insulin receptors were identified using 125I-labelled insulin and isolated hepatocytes in vitro. Scatchard analysis was interpreted in terms of high affinity (KD 4 nM) and low affinity (KD 80 nM) receptors for insulin. No change in the affinity of either receptor site was detected during pregnancy or lactation; There was, however, a significant increase in the number of both types of receptor on the hepatocyte by day 12 of pregnancy which was maintained until at least day 20 of pregnancy. During lactation, the number of receptors declined to values similar to those of virgin rats. Serum insulin concentrations, determined by radioimmunoassay, were elevated during pregnancy, returned to values similar to virgin rats during early lactation and were significantly reduced compared with virgin rats by day 15 of lactation. These results illustrate that physiological conditions exist whereby the number of insulin receptors may increase, despite elevated serum insulin concentrations, in apparent conflict with the 'down-receptor' hypothesis.

Citations

Jan 1, 1989·The Proceedings of the Nutrition Society·R G Vernon
Aug 25, 1980·FEBS Letters·D H Williamson
Jun 1, 1984·Metabolism: Clinical and Experimental·M B Davidson
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MassimiL Dini
Jun 1, 1983·The Proceedings of the Nutrition Society·R G Vernon, D J Flint
May 1, 1992·The American Journal of Physiology·M BalageJ Grizard
Jan 1, 1984·The American Journal of Physiology·A LeturqueJ Girard
Jan 1, 1990·The American Journal of Physiology·M ChiangC S Nicoll
Nov 1, 1986·The American Journal of Physiology·A F BurnolJ Girard
Oct 1, 1983·The American Journal of Physiology·A F BurnolJ Girard
Nov 1, 1980·Molecular and Cellular Endocrinology·D J FlintR G Vernon

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