Changes in the number of polymorphonuclear leukocytes and concentrations of IL-8 and granulocyte elastase in the vaginas of normal pregnant women

American Journal of Reproductive Immunology : AJRI
Tetsuo YamadaI Sato

Abstract

It is unknown whether the number of vaginal polymorphonuclear leukocytes (vPMNs) of healthy pregnant women changes during pregnancy. We studied 23 women after 14.7 +/- 3.6 weeks, 37 women after 25.2 +/- 3.1 weeks, and 26 women after 32.9 +/- 2.0 weeks of gestation. Numbers of total vPMNs, viable vPMNs, dead vPMNs, percentage viability of vPMNs, and concentrations of IL-8 and elastase activity were determined in vaginal washings. The vPMNs, including viable and dead vPMNs, significantly increased with advancing gestation from 9.9 +/- 8.6 x 10(5) to 13.1 +/- 13.4 x 10(5), and to 27.1 +/- 26.6 x 10(5) (r=0.315, P < 0.01). Vaginal IL-8 significantly increased with advancing gestation. However, increases in vaginal elastase activity did not occur. These results suggested that an increase in vPMNs is an early event, and that the increase in vaginal elastase activity is a late event in relation to the ripening of the uterine cervix.

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Citations

May 27, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Gordana MijovićMarina Bujko
Jul 19, 2011·ISRN Obstetrics and Gynecology·Sebastián GaliñanesBeatriz Perazzi
Jan 16, 2009·American Journal of Reproductive Immunology : AJRI·Magdalena Pertyńska-MarczewskaJan Wilczyński
Jun 30, 2006·Journal of Reproductive Immunology·Kotaro KunimiMinoru Irahara
Dec 31, 2004·Obstetrics and Gynecology·Jennifer F CulhaneSecondo Guaschino
Dec 31, 2004·Obstetrics and Gynecology·Patrick S RamseyJohn C Hauth

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