Changes in the optical properties of liposome dispersions in relation to the interlamellar distance and solute interaction

Chemistry and Physics of Lipids
L I VieraE A Disalvo

Abstract

The changes in absorbance produced when liposomes are subject to increasing osmotic pressures were correlated with the distance at which the undulation, hydration and steric repulsions dominate. It is found that at low pressures, when the bilayers are apart by more than 1 nm, the absorbance decreases with the decrease in the bilayer distance. However, at higher pressures where the bilayer are in contact within 0.7 nm the absorbance increases with the increase in pressure. This is well explained by the scattering law for particles of diameter comparable to the wavelength and fits with the empirical Bangham's law used for permeability assays. At much higher pressures, a break in the absorbance at 0.5 nm of the interbilayer distance denotes that absorbance is sensitive to the perturbation when steric forces dominate. These effects were compared to those obtained with solutes that may replace water at the membrane interface by hydrogen bonding. The results indicate that the membrane approach produces a similar effect to sucrose on both calorimetric and optical properties, suggesting that the bilayer interaction promotes a partial dehydration or reorganization of the water at the interface. The relevance of these findings on the per...Continue Reading

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Citations

Jul 20, 2007·Biotechnology Letters·Nadia S ChiaramoniSilvia Del V Alonso
Nov 1, 1996·Chemistry and Physics of Lipids·E A DisalvoE A Lissi
Apr 17, 2003·Experimental Eye Research·Daxin TangDonald B DuPré
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·K PohlmeyerR Wagner
Jan 13, 2015·Chemistry, an Asian Journal·Junji TakeuchiHideya Yuasa
Oct 21, 2005·Analytical Biochemistry·Aleksandar VojtaEnrico Schleiff
Sep 10, 2014·The Journal of Physical Chemistry. B·Magda PrzybyłoMarek Langner
May 10, 2015·Chemistry and Physics of Lipids·M AhumadaE A Lissi

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