Changes in the pathogenesis and prevention of chronic lung disease of prematurity

American Journal of Perinatology
E Bancalari

Abstract

With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild initial respiratory distress and therefore do not receive aggressive ventilation, it is clear that factors other than oxygen toxicity and barotrauma are involved in the pathogenesis of this new milder type of CLD. CLD results from the interaction of multiple factors that can injure the immature lung. For this reason the prevention must be based on the elimination of all the factors implicated in its pathogenesis. Clinical and epidemiological data strongly suggest that infections, either prenatal or nosocomial, and the presence of a patent ductus arteriosus (PDA) play a major role in the development of CLD in these infants. For this reason, efforts to prevent CLD in extremely low birth weight infants should include an aggressive approach to the prevention and treatment of prenatal and neonatal infections and an early closure of the PDA.

Citations

Jun 5, 2003·Early Human Development·Jacqueline BauerOtwin Linderkamp
Feb 26, 2004·Paediatric Respiratory Reviews·Christian P Speer
Apr 23, 2003·Respiratory Physiology & Neurobiology·Gerd SchmalischAndreas Patzak
Nov 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·W F MalcolmC M Cotten
May 25, 2006·Acta Paediatrica·Lilian S Teixeira, Patrick J McNamara
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marta SzymankiewiczJanusz Gadzinowski
Mar 18, 2009·Journal of Paediatrics and Child Health·Adam B Hoellering, Lucy Cooke
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P BallabhS Cunningham-Rundles
Dec 3, 2005·American Journal of Respiratory and Critical Care Medicine·Luciana FriedrichMarcus H Jones
Mar 21, 2003·Pediatric Research·Boris W KramerMachiko Ikegami
Apr 25, 2009·Pediatric Research·Richard L Auten, Jonathan M Davis
Sep 29, 2004·Paediatric Drugs·Carl T D'Angio, William M Maniscalco
Jul 13, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Geoffrey A AgronsRichard I Markowitz
Jan 3, 2014·Antioxidants & Redox Signaling·Phyllis A Dennery
Apr 9, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Mayra Freeman-LaddJames C Huhta
Nov 21, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rafik MargaryanBruno Murzi
Dec 17, 2008·Experimental Lung Research·Philipp von BismarckStefan Rose-John
Jul 9, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M RichardP Gérardin
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Ofer Levy
Apr 7, 2010·Clinics in Perinatology·Robert H Pfister, Jay P Goldsmith
Aug 1, 2009·The Journal of Pediatrics·Kathryn Browning CarmoMary Paradisis
Feb 25, 2009·Critical Care Nursing Clinics of North America·Debbie Fraser Askin, William Diehl-Jones
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Scott TschuppertAli Dodge-Khatami
Nov 7, 2007·Seminars in Fetal & Neonatal Medicine·Win Tin, Thomas E Wiswell
Mar 31, 2007·Clinics in Perinatology·Thomas E WiswellKirsten Ohler
Feb 8, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Chang Won ChoiJung Yun Choi
Jun 1, 2007·Acta Paediatrica·Augusto SolaRichard Deulofeut
Mar 27, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Masatoshi KondoSusumu Itoh
Oct 12, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jamie BenthamNeil Wilson
Jul 25, 2006·Seminars in Perinatology·Patricia R ChessWilliam M Maniscalco
Sep 27, 2005·The Journal of Pediatrics·Amer AmmariRichard A Polin
Jul 30, 2005·The Veterinary Clinics of North America. Equine Practice·Virginia A Buechner-Maxwell
Sep 7, 2006·Psychological Assessment·Sheri P EisengartSonia Minnes
May 29, 2002·Toxicology and Applied Pharmacology·Barry WeinbergerJeffrey D Laskin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
A H Jobe, E Bancalari
Biology of the Neonate
E Bancalari, T del Moral
© 2021 Meta ULC. All rights reserved