PMID: 8515327Apr 1, 1993

Changes in the pattern of drug overdoses

Journal of General Internal Medicine
M D SteinT J Wachtel


To describe changes in the pattern of patients with drug overdoses hospitalized over the past two decades. Retrospective data review. A 719-bed university-affiliated hospital. All adults admitted to the hospital with drug overdoses in 1968, 1979, and 1989. Changes in demographics, drugs used, and discharge disposition. A majority of patients admitted with drug overdoses have had previous suicide attempts; and while women predominate, they make up a decreasing proportion of admissions over time (76% in 1968 to 52% in 1989 (p = 0.003). Benzodiazepines were the drugs most commonly used in 1979 and 1989, and cocaine has shown a marked increase in use over time, while barbiturate overdoses have progressively decreased. The use of two or more drugs is common and has been consistent over time, as has been the concomitant use of alcohol. The mortality rate has remained low at 1%, but mean length of stay has decreased dramatically from 6.6 days in 1979 to 3.2 days in 1989 (p < 0.001) and discharge disposition has shifted from out-patient to inpatient psychiatric care. The majority of patients admitted to a general acute care hospital following a drug overdose have a history of previous suicide attempts and are followed by a mental healt...Continue Reading


Aug 1, 1979·Annals of Internal Medicine·J A Lorch, S Garella
Jan 14, 1978·British Medical Journal·A T Proudfoot, J Park
Oct 1, 1977·Archives of General Psychiatry·J P O'Brien
May 10, 1976·JAMA : the Journal of the American Medical Association·D H Rosen
Jan 1, 1976·The American Journal of Drug and Alcohol Abuse·M A Brandwin
Sep 1, 1991·Archives of Internal Medicine·D K Wysowski, C Baum
Sep 1, 1990·The American Journal of Emergency Medicine·T L LitovitzK M Bailey
Nov 21, 1986·Science·N J Kozel, E H Adams
Oct 1, 1986·The American Journal of Psychiatry·J BradyI L Muszynski
Dec 1, 1985·American Journal of Public Health·R BouknightR Hoppe
Jun 1, 1974·Archives of General Psychiatry·M M Weissman
Jan 1, 1981·Annals of Emergency Medicine·A R Soslow
Apr 20, 1984·JAMA : the Journal of the American Medical Association·T A SternG E Thibault
Nov 1, 1981·Social Science & Medicine. Part E, Medical Psychology·U BustoE M Sellers
Apr 24, 1980·The New England Journal of Medicine·G E ThibaultE R Skinner


Aug 9, 2001·Irish Journal of Medical Science·G T McMahon, K McGarry
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·T HayaseY Fukui
Jul 1, 1996·Psychological Medicine·J Prosser, P McArdle
Dec 19, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Milan R RadovanovićMirjana S Radovanović
Sep 25, 2002·Human & Experimental Toxicology·A F Ab Rahman
Jan 21, 2020·The Australian and New Zealand Journal of Psychiatry·Mariann JacksonGregory Carter
Jun 5, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Andre LoJanet Raboud

Related Concepts

Hospital Stay
Patient Referral
Retrospective Studies
Suicide Attempt
Drug Overdose

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Medical & Biological Engineering & Computing
P H VeltinkJ A van Alsté
British Medical Journal
L F Prescott, M S Highley
© 2021 Meta ULC. All rights reserved