Changes in the patterns of RNA synthesis in early embryogenesis of Xenopus laevis.

Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
K ShiokawaM Oh-uchida

Abstract

We analyzed the accumulation of newly-synthesized heterogeneous mRNA-like RNA, 4 S RNA, 5 S RNA, snRNAs and rRNA before and after the midblastula transition (MBT) in Xenopus laevis embryogenesis. Based on the kinetics of the labeling, we concluded that the pattern of RNA synthesis in Xenopus embryogenesis changes following at least three characteristically different phases. The first phase is the pre-MBT stage, which is characterized by the synthesis of heterogeneous mRNA-like RNA, accompanied by the synthesis of small amounts of 4 S RNA, 5 S RNA and snRNAs. The second phase is the MBT stage which is characterized by a large activation (about 50-fold increase on a per cell basis) of 4 S RNA synthesis. The third phase is the post-MBT stage which is characterized by the commencement and increase in rRNA synthesis. We assume that RNA polymerases II, III and I are activated in this order in early Xenopus embryogenesis.

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Citations

Jun 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Irina LagutinaCesare Galli
Jan 18, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Irina LagutinaCesare Galli
Sep 12, 2012·Cellular and Molecular Life Sciences : CMLS·Olga ØstrupPhilippe Collas
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Majumder, M L DePamphilis
Oct 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Sean Brennan, Robert Savage
Mar 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Koichiro ShiokawaKeiichi Hosokawa
Jan 1, 1994·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Yannick Andéol
Mar 13, 1999·The Journal of Biological Chemistry·P LawingerS Majumder
May 1, 1994·Journal of Cellular Biochemistry·S Majumder, M L DePamphilis

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