PMID: 2494284Feb 1, 1989Paper

Changes in the plasma concentrations of inhibin throughout the normal sheep oestrous cycle and after the infusion of FSH

The Journal of Endocrinology
A S McNeillyD T Baird

Abstract

A radioimmunoassay for inhibin was developed using a peptide containing the 1-26 amino acid sequence of the N-terminus of the alpha-chain of 32 kDa porcine inhibin as immunogen, and 125I-labelled tracer. Evaluation of this assay using Sephadex column chromatography, chromatoelectrophoresis and immunoblotting confirmed that it measured all forms of inhibin present in sheep follicular fluid and was suitable for measurement of inhibin in sheep plasma. There was no evidence of the presence of free alpha-subunit in either sheep follicular fluid or ovarian vein plasma. The concentration of inhibin in jugular plasma throughout the follicular and luteal phases of four ewes with ovarian autotransplants was measured. The ovarian secretion of inhibin and oestradiol were also measured simultaneously throughout the follicular phase in a spontaneous cycle and after infusion of NIH-oFSH-S14 at 10 micrograms/h for 48 h following premature luteal regression induced by prostaglandin. The results showed: (1) no change in the peripheral concentration of inhibin throughout the cycle except an increase related to the periovulatory increase in FSH and LH. (2) Following luteal regression, the concentration of FSH fell as the secretion rate of oestradi...Continue Reading

Citations

Apr 1, 1993·Domestic Animal Endocrinology·R Braw-TalE Gootwine
Mar 20, 1998·Animal Reproduction Science·R Boukhliq, G B Martin
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·D L HealyD De Kretser
Feb 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Hiroyuki KanekoNaomi Kashiwazaki
Mar 28, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·J M YoungA S McNeilly
Jul 12, 2011·Molecular and Cellular Endocrinology·Alan S McNeilly
Jul 11, 1991·Clinical Endocrinology·S G HillierA S McNeilly
Apr 3, 2008·The Journal of Clinical Endocrinology and Metabolism·A W HorneW C Duncan
Jul 1, 1990·Journal of Endocrinological Investigation·D M de KretserG P Risbridger
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·D M Robertson

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