PMID: 6980955Sep 1, 1982Paper

Changes in the proteins of wool following treatment of sheep with epidermal growth factor

The Journal of Investigative Dermatology
J M GillespieD M Robertson

Abstract

Administration of epidermal growth factor (EGF) extracted from mouse submaxillary gland to Merino sheep resulted in a temporary inhibition of the activity of the wool follicles. Subsequently, either complete discontinuities appeared in the fibers resulting in shedding of the entire fleece, or incomplete, in which case the fleece was retained but bore a zone of weakness. The protein composition of the first sample of wool harvested from 1 sheep following infusion for 66 hr with 27.5 mg EGF (0-2 weeks posttreatment) was similar to pretreatment wool. This represented wool fibers which were already present in the follicles at the beginning of infusion. Thereafter, the composition of the wool changed progressively, reaching a maximum divergence from the control in the 3-4 week regrowth period followed by a return to normal by about 10 weeks. Over this period the content of high-sulfur proteins first rose from an initial 19% to a maximum of 30%, then returned to 19%, while the high-tyrosine protein content initially decreased from 12% to 5% and then slowly increased to 12%. In addition to changes in overall protein composition, two-dimensional electrophoresis revealed alterations in the proportions of some individual protein componen...Continue Reading

References

Aug 1, 1975·Australian Journal of Biological Sciences·M J FrenkelP J Reis
Mar 1, 1966·The Biochemical Journal·J M Gillespie, P J Reis
Feb 1, 1981·The Journal of Endocrinology·G P MooreD Robertson
May 1, 1980·Australian Journal of Biological Sciences·J M GillespieP J Reis

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Citations

Jan 1, 1991·Electron Microscopy Reviews·R C MarshallJ M Gillespie
Aug 1, 1985·Seminars in Arthritis and Rheumatism·C W Castor, A R Cabral
Jan 1, 1992·The Journal of Investigative Dermatology·D L du CrosG P Moore
Feb 1, 1994·The Journal of Investigative Dermatology·A FratiniG E Rogers

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