PMID: 24356757Dec 21, 2013Paper

Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk

Singapore Medical Journal
Dumnoensun PruksakornPeraphan Pothacharoen

Abstract

To prevent long-term unfavourable consequences to the articular cartilage of weight-bearing joints, serum biomarkers can be used to identify optimum loading of activities. This study aimed to investigate the circulation pattern of serum cartilage biomarkers in healthy adults in response to an uphill walk. This study recruited 58 healthy participants for the experimental group and 24 matched participants for the control group. Participants in the experimental group walked continuously for 14 km on a pathway with a 5.97° incline, while participants from the control group walked on a horizontal pathway. Serum was collected from both groups preactivity (i.e. T1), immediately after activity (i.e. T2) and 24 hours after T1 (i.e. T3). The serum cartilage oligomeric matrix protein (COMP), chondroitin sulfate-WF6 (WF6) and hyaluronic acid (HA) levels at each time point were quantified using enzyme-linked immunosorbent assays, and the results analysed. Both groups shared similar demographic characteristics and activity duration. At T2, the serum COMP level of the experimental group was significantly higher than that of the control group, but the serum HA level of the experimental group was significantly lower than that of the control gro...Continue Reading

Citations

May 12, 2016·Journal of Sports Sciences·Annegret MündermannHenner Hanssen
Jun 18, 2016·Journal of Physical Therapy Science·Su Youn Cho, Hee Tae Roh
Mar 22, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masayuki MizunoTakeshi Okanoue
Jun 27, 2017·The American Journal of Sports Medicine·Annegret MündermannUwe Schütz
Jan 26, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sara FirnerAnja Niehoff

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