Changes in the specific surface area of tablets composed of pharmaceutical materials with various deformation behaviors

Drug Development and Industrial Pharmacy
Virginie BusigniesPierre Tchoreloff

Abstract

The aim of this work is to study the effect of compaction on the specific surface area of tablets composed of various pharmaceutical materials (microcrystalline cellulose, lactose, and anhydrous calcium phosphate) compacted under seven degrees of compaction pressure. In a first part, the influence of the deformation behavior of the compacted materials on the evolution of the specific surface area is observed. In a second part, the brittle and ductile abilities of the materials are calculated using the specific surface area values. The experimental results are used to calculate the number and the force of interparticulate bonds inside the tablet. Tablets made of microcrystalline cellulose, which deform plastically, have specific surface areas that fall under pressure. In the case of lactose, the tablet specific surface area first increases to reach a maximum value at a pressure of 150 MPa. At higher pressure, however, the specific surface area decreases. The specific surface area of tablets composed of anhydrous calcium phosphate consistently increases, whatever the compaction pressure applied. Moreover, the evolution of the specific surface area is correlated with the tensile strength of the corresponding tablets. The number an...Continue Reading

References

Dec 1, 1972·The Journal of Pharmacy and Pharmacology·N A Armstrong, R F Haines-Nutt
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Aug 12, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S WestermarckJ Yliruusi
Dec 28, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S WestermarckJ Yliruusi
Sep 29, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·V BusigniesG Couarraze
May 16, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·V BusigniesP Tchoreloff
May 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Virginie BusigniesPierre Tchoreloff
Aug 16, 2008·Journal of Pharmaceutical Sciences·J NordströmG Alderborn
Oct 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ingvild KlevanGöran Alderborn

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Citations

May 10, 2012·Drug Development and Industrial Pharmacy·Lizbeth MartínezPaul M Young
Feb 7, 2012·Drug Development and Industrial Pharmacy·Patrick OkoyeRutesh H Dave
Aug 15, 2013·Pharmaceutical Development and Technology·Raman Mahadevan IyerWaseem Malick
Dec 25, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Steve R MarekHugh D C Smyth
Oct 17, 2018·Pharmaceutics·Ramon CabiscolArno Kwade
Dec 29, 2020·Journal of Pharmaceutical Sciences·Rahul Roopwani, Ira S Buckner

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