PMID: 18405520Apr 15, 2008Paper

Changes in the spectral characteristics of ventricular fibrillation in lesions produced by radiofrequency ablation. An experimental study

Revista española de cardiología
Francisco J ChorroLuis Such

Abstract

Although electro- physiological databases contain information about changes in the time domain in lesions produced by radiofrequency ablation, very few data on changes in the frequency domain are available. The aim of this study was to investigate changes in the spectral characteristics of ventricular fibrillation in zones with radiofrequency lesions. Recordings of ventricular fibrillation were obtained in 11 isolated perfused rabbit heart preparations using a multiple epicardial electrode located on the left ventricular free wall. Spectral parameters derived by Fourier analysis before and after the creation of transmural radiofrequency lesions were compared. In the ablated zones, significant reductions were observed in the spectral density of the dominant (0.168+/-0.113 mV(2)/Hz vs 0.025+/-0.018 mV(2)/Hz; P< .001) and mean frequencies (0.053+/-0.057 mV(2)/Hz vs 0.012+/-0.016 mV(2)/Hz; P< .001), the normalized energy around the dominant frequency (0.860+/-0.570 vs 0.128+/-0.091; P< .001), and the standard deviation of the power spectrum (0.031+/-0.020 mV(2)/Hz vs 0.004+/-0.001 mV(2)/Hz; P< .001). There was no significant change in the dominant (16.2+/-5.6 vs 14.8+/-1.8 Hz) or mean frequency (17.7+/-3.4 vs 16.6+/-1.3 Hz). The sp...Continue Reading

References

May 10, 2001·Journal of the American College of Cardiology·T WolfS A Ben-Haim
Nov 13, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Francisco J ChorroLuis Such
Nov 19, 2004·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Corinna B BrunckhorstWilliam G Stevenson

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Citations

Dec 18, 2012·Pacing and Clinical Electrophysiology : PACE·Francisco J ChorroLuis Such

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