Changes in the structural properties of peripheral nerves after transection

The Journal of Hand Surgery
E B TobyG Alvine

Abstract

Changes in peripheral nerve structural properties after transection were measured weekly for 5 weeks in the distal stump of the sciatic nerve in 50 Sprague-Dawley rats. Each week after transection, the distal stump of the transected nerve showed increased stiffness when compared to intact nerves. Linear elastic stiffness reached a maximum at weeks 1 and 2 after transection, when the transected nerves were 15% stiffer than the contralateral control sides. Toughness was also increased and reached a maximum at week 4 with a 50% difference between values for experimental and control sides. Overall failure load was between 21% and 27% greater, peaking at week 3. An increase in stiffness of the distal stump would result in increased tension at the suture line, as the nerve gap is overcome when performing a delayed neurorraphy. These data suggest, with respect to structural properties, that an end-to-end repair should be carried out at the time of injury; after only 1 week, significant stiffness in the distal segment of the nerve developed, which should result in an increase in tension at the repair site.

References

Dec 1, 1979·Acta Orthopaedica Scandinavica·J P KendallR A Dickson
Sep 1, 1976·The Journal of Hand Surgery·F W BoraN A Didizian
Jun 1, 1992·Acta Orthopaedica Scandinavica·M K KwanS R Garfin
Jul 1, 1992·The Journal of Hand Surgery·W L ClarkA F Tencer
Sep 1, 1991·The Journal of Hand Surgery·E J WallS R Garfin
Mar 1, 1969·Journal of Neurosurgery·T B DuckerG J Hayes
Jan 1, 1980·The Journal of Hand Surgery·F W BoraJ Black

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Citations

Sep 10, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·James KernsMark Gonzalez
Aug 14, 1999·The Journal of Hand Surgery·E B TobyA Struthers

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