Changes in the thalamocortical connectivity during anesthesia-induced transitions in consciousness

Neuroreport
Sung-Phil KimJee Hyun Choi

Abstract

Thalamocortical networks play an important role in information integration during consciousness. However, little is known about how the information flows between the thalamus and the cortex are affected by a loss of consciousness. To investigate this issue, we analyzed effective connectivity between the cortex and the thalamus in animals during anesthesia-induced transitions. By recording the electroencephalogram from the primary motor and the primary somatosensory cortex and by recording local field potentials from the ventral lateral and the ventrobasal thalamic nuclei, we evaluated changes in the conditional Granger causality between cortical and thalamic electrical activity as mice gradually lost consciousness from the use of anesthesia (ketamine/xylazine). The point of loss of consciousness was indicated by a moment of loss of movement that was measured using a head-mounted motion sensor. The results showed that 65% of the thalamocortical information flows were changed by anesthesia-induced loss of consciousness. Specifically, the effective connectivity between the cortex and the ventral lateral thalamus was altered such that the primary motor and the primary somatosensory cortex Granger-caused the ventral lateral thalamus...Continue Reading

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Citations

Jun 30, 2015·The European Journal of Neuroscience·Takahiro Noda, Hirokazu Takahashi
May 7, 2013·Brain Research·Alessandra LintasAlessandro E P Villa
Sep 21, 2013·Journal of Neurophysiology·Kristin K SellersFlavio Fröhlich
Jul 18, 2020·Scientific Reports·Franca WagnerClaus Kiefer
Dec 5, 2019·Frontiers in Systems Neuroscience·Siouar BensaidPascal Benquet
Nov 1, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Lawrence M Ward
May 26, 2018·Journal of Biophotonics·Jayyoung BaeJae G Kim
Feb 8, 2021·NeuroImage·Corson N AreshenkoffJason P Gallivan
Jan 6, 2022·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Matti GärtnerSimone Grimm

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