PMID: 9545108Apr 17, 1998Paper

Changes in the thyroid technetium-99m scintigram after antithyroid and subsequent radioiodine treatment for solitary autonomous nodules

Thyroid : Official Journal of the American Thyroid Association
B Nygaard

Abstract

In patients with solitary autonomous thyroid nodules, the treatment of choice is radioiodine (131I) therapy, eventually preceded by antithyroid drugs to avoid aggravation of hyperthyroidism. The aim of this study was to evaluate the scintigraphical results of 131I treatment when using antithyroid pretreatment. Twenty-four patients having a solitary autonomous thyroid nodule were studied. A technetium-99m (99mTc) pertechnetate scintigraphy was performed at the time of diagnosis, when serum thyrotropin (TSH) had been normal for about 3 months on antithyroid drug treatment, and finally when serum TSH was normalized after 131I treatment. The primary scintigram showed suppression of 99mTc pertechnetate in the paranodular thyroid tissue in all patients. The second scintigram showed normal uptake in the paranodular tissue in 22 patients and a continuing suppression of the paranodular tissue in 2 patients. The third scintigram showed a solitary adenoma in 14 patients with none or almost no uptake in the paranodular tissue, resembling the first scintigram. In 6 patients an adenoma was still present, but uptake was seen in the paranodular tissue; in 3 patients a homogenous uptake without any sign of the previous nodule, and in 1 patient ...Continue Reading

References

Apr 1, 1982·Acta Endocrinologica·H BliddalK Siersbaek-Nielsen
Dec 15, 1983·The New England Journal of Medicine·R Goldstein, I R Hart
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·B NygaardJ M Hansen
Sep 1, 1995·Clinical Endocrinology·A E JarløvJ M Hansen
Oct 1, 1996·European Journal of Endocrinology·C FerrariA Paracchi
Apr 1, 1997·Thyroid : Official Journal of the American Thyroid Association·J C Sisson

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Citations

Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Eugenio ReschiniPaolo Gerundini
Nov 1, 2003·Thyroid : Official Journal of the American Thyroid Association·Helle DøssingLaszlo Hegedüs
Aug 30, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hemanth BolusaniJohn H Lazarus
Feb 26, 2005·Clinical Endocrinology·Claudia CeccarelliAldo Pinchera

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