PMID: 15374511Mar 1, 1990Paper

Changes in the transmural distribution of antioxidant enzyme activities across the left ventricle heart wall from rats fed ad libitum or food-restricted during growth and aging

Archives of Gerontology and Geriatrics
I SimonettiE Bergamini

Abstract

Data on vulnerability to injury and on the larger age-related accumulation of lipofuscin in the subendocardial myocardium prompted us to investigate the changes in the levels and in the transmural distribution of catalase (C), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities across the left ventricle heart wall of rats fed ad libitum a standard diet or submitted to intermittent feeding during growth and aging. Enzyme activities were assayed by standard techniques on subepicardial, midmyocardial or subendo- cardial tissue obtained by cutting the heart wall into 100-microm-thick sections at the cryostat. The levels of GSH-Px and of C (but not of SOD) activity increased with age and reached their highest values in the subendocardial region by adulthood or senescence, respectively. No effect was observed of intermittent feeding on age-related changes in enzyme levels and transmural distribution.

References

Jan 1, 1975·Annual Review of Biochemistry·I Fridovich
Mar 1, 1991·Aging : Clinical and Experimental Research·A Del RosoE Bergamini
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·V De TataE Bergamini
Jan 1, 1988·Free Radical Biology & Medicine·D V Godin, S A Wohaieb
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·I A CotgreaveS Orrenius
Jun 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·M ScarpaL Battistin
Feb 1, 1985·Journal of Biomechanical Engineering·T Arts, R S Reneman
May 1, 1985·Journal of Gerontology·M HiguchiJ O Holloszy
Oct 1, 1985·Journal of Applied Physiology·M M KanterA J Merola
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·B Tota
May 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·C J Lammi-KeefeP V Hegarty
Jan 1, 1983·Pflügers Archiv : European journal of physiology·V De TataE Bergamini
Jan 1, 1982·Gerontology·C L GoodrickN L Cider
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M E TappelA L Tappel

❮ Previous
Next ❯

Citations

Nov 16, 2004·Mechanisms of Ageing and Development·Alex BokovArlan Richardson

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.