PMID: 2479153Jul 1, 1989Paper

[Changes in the ultrastructure of rat hepatocyte nucleoli during bilateral adrenalectomy and after administration of cortisol].

T︠S︡itologii︠a︡ i genetika
T V MdivaniG D Tumanishvili

Abstract

Nucleolar ultrastructure of the rat hepatocytes after bilateral adrenalectomy and cortisol stimulation has been studied by the electron-microscopic method Traits of nucleolar inactivation (a decrease of granular component enlargement of fibrillar centres, condensation of peri- and intranucleolar chromatin, etc.) are observed in hepatocyte nucleoli 5 days after adrenalectomy. Cortisol stimulation of hepatocytes of the adrenalectomized rats leads to nucleolar activation (4h, 5h, 8h after the hormone injection). Adrenalectomy with following cortisol injection is a useful model to study inactivation and activation of ribosomal genes in the target cells.

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