PMID: 3765987Jan 1, 1986Paper

Changes in the ultrastructure of the hypothalamus during chronic morphine poisoning

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova
G V Kolusheva

Abstract

Using electron microscopy the author studied the changes in the ultrastructure of the ventromedial hypothalamic nucleus in Wistar rats with chronic morphine intoxication (induced by unchanged or build-up doses) and upon discontinuation of morphine. Chronic morphine intoxication exerted an adverse effect on the cellular protein synthesis as well as on vesicular, granular and membranous components of cells. A correlation was detected between the pathomorphological alterations and the morphine dose. The study revealed a high sensitivity to morphine of neurons, large dendrites and interneuronal links in the period of dependence formation and the greatest vulnerability of cells and their processes during abstinence, particularly under conditions of a sharp discontinuation of morphine build-up dosage. Destructive processes observed in the experiment were also attended by manifestations of the compensatory, reparative and restorative processes detected on the 7th day after morphine discontinuation.

Related Concepts

Related Feeds

3D Cellular Models of Brain and Neurodegeneration

Brain organoids are three-dimensional in vitro cellular models of the brain that can recapitulate many processes such as the neurodevelopment. In addition, these organoids can be combined with other cell types, such as neurons and astrocytes to study their interactions in assembloids. Disease processes can also be modeled by induced pluripotent stem cell-derived organoids and assembloids from patients with neurodegenerative disorders. Discover the latest research on the models here.

Related Papers

Bulletin of Experimental Biology and Medicine
S A LobanovG F Arslanova
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova
L B Verbitskaia, N N Bogolepov
Biulleten' eksperimental'noĭ biologii i meditsiny
L B VerbitskaiaN I Pavlovskaia
Biulleten' eksperimental'noĭ biologii i meditsiny
I I SemenchenkoE N Popova
© 2021 Meta ULC. All rights reserved