Changes in theophylline metabolism during postnatal development in rat liver slices

Biochemical Pharmacology
R GorodischerZ Ben-Zvi

Abstract

The metabolism of theophylline was studied in liver slices of young and adult rats. Theophylline and six metabolite fractions were recognized in adult liver by thin-layer radiochromatography and high performance liquid chromatography: 1-methyluric acid; 1-methylxanthine; 1,3-dimethyluric acid and/or 3-methylxanthine; caffeine; a uracil derivative and two unknown polar compounds. Preincubation with caffeine or theobromine inhibited theophylline metabolism. Allopurinol decreased the formation of three metabolite fractions but markedly increased the production of 1-methylxanthine. SKF 525-A inhibited the overall metabolism of theophylline. The specific activity of the enzyme system was 3.2 +/- 0.4 nmoles X (g liver)-1 X hr-1 in the 4- to 5-day-old rat and increased to a peak of 25.7 +/- 1.7 in the 28-day-old; values for Km and Vmax in the 7- and 28-day-olds were 132.1 and 67.5 microM, and 23.9 and 52.1 nmoles X (g liver)-1 X hr-1 respectively. Theophylline and the same six metabolites were identified in young and adult rats, but the development pattern was not uniform. Peak age-related activity and involvement of mixed-function oxidase system are features which are common to theophylline and caffeine metabolism. Xanthine oxidase p...Continue Reading

References

Dec 14, 1979·Science·J V ArandaR Haber
Jan 1, 1986·European Journal of Clinical Pharmacology·R GorodischerM J Arnaud
Jan 1, 1982·European Journal of Clinical Pharmacology·R Gorodischer, M Karplus
May 1, 1981·Clinical Pharmacology and Therapeutics·K Y TserngF N Takieddine
Apr 1, 1981·Pediatric Research·M BonatiR Parini
Dec 1, 1981·Biochemical Pharmacology·D WarszawskiR Gorodischer
Oct 1, 1980·Clinical Pharmacology and Therapeutics·J J Grygiel, D J Birkett
May 1, 1980·Biomedical Mass Spectrometry·J L BrazierB Salle
Feb 1, 1981·Clinical Pharmacology and Therapeutics·R L Manfredi, E S Vesell

❮ Previous
Next ❯

Citations

Jan 1, 1995·Life Sciences·A R ParrishK Brendel
Jan 1, 1990·Drug Metabolism Reviews·F Gaspari, M Bonati
Apr 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F BerthouA Guillouzo
Dec 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G O KokwaroG Edwards
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Noriko MatsunagaEmi Nakashima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
H V SheeversA J Gandolfi
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
P A MeredithJ L Reid
European Journal of Applied Physiology and Occupational Physiology
G B MeeseM I Lewis
Biology of the Neonate
P ForgetJ Senterre
© 2021 Meta ULC. All rights reserved