Changes in thick filament structure during compression of the filament lattice in relaxed frog sartorius muscle.

Journal of Muscle Research and Cell Motility
T C Irving, B M Millman

Abstract

Equatorial X-ray diffraction patterns from relaxed, chemically-skinned frog sartorius muscles under a range of external osmotic pressures from 0 to 290 torr have been analysed and compared to the pattern from the relaxed intact muscle. Lattice spacings and electron density diagrams were determined as a function of external pressure. Reflection intensities, averaged over small ranges of pressures, were determined out to the 4,0 reflection; phases for the first five orders were established as ++--+ over the whole pressure range. As external pressure was increased, lattice spacing decreased, as did full width at half maximum density for both thick and thin filaments. Most of the lattice spacing and thick filament compression occurred at low pressure, whereas thin filaments were compressed proportionally to pressure over the whole pressure range. These conclusions were confirmed by fitting cylindrical models for filament density to the X-ray diffraction patterns. Axially-projected electron density across the A-band filament lattice showed that in relaxed muscle the thick filament projections (myosin heads) are concentrated in regions between adjacent thick filaments, as far as possible from the thin filaments, and they tend to beco...Continue Reading

References

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Citations

Aug 1, 1992·Journal of Muscle Research and Cell Motility·N Yagi
Feb 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Younss Ait-MouPieter P de Tombe
Sep 12, 2018·International Journal of Molecular Sciences·Weikang MaThomas Irving
Feb 1, 1992·Journal of Muscle Research and Cell Motility·T C Irving, B M Millman
Jun 1, 1995·Journal of Muscle Research and Cell Motility·C J Hawkins, P M Bennett
Jul 20, 2018·International Journal of Molecular Sciences·Felicity EakinsJohn M Squire
Jan 12, 2002·Circulation Research·John P KonhilasPieter P de Tombe
Sep 3, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Priya MuthuDanuta Szczesna-Cordary
Apr 30, 1998·Physiological Reviews·B M Millman
Jan 27, 2007·Journal of Molecular Biology·Brett A ColsonRichard L Moss
Aug 10, 2021·Circulation Research·Weikang MaThomas Irving
Apr 25, 2000·Biophysical Journal·T C Irving, D W Maughan
Sep 22, 2012·Biophysical Journal·Bertrand C W TannerMark S Miller

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