PMID: 18407071Jan 1, 1992Paper

Changes in thyroid function in nonthyroid illness

Trends in Endocrinology and Metabolism : TEM
T K Wong, J M Hershman

Abstract

Nonthyroid illness can cause changes in thyroid function that have been described as low triiodothyronine (T(3)) and low thyroxine (T(4)) states. Reduced peripheral conversion of T4 to T(3) explains the low serum T(3) concentration. The explanation for the low serum T(4) level is multifactorial; whether free-thyroxine (FT(4)) level is normal or reduced remains controversial. Cytokines such as tumor necrosis factor alpha, which are produced by the immune system during severe illness, may inhibit thyroid function directly and be responsible for the changes in pituitary-thyroid function.

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Citations

Dec 1, 1996·Biological Trace Element Research·G NapolitanoF Monaco
Jan 1, 1995·Trends in Endocrinology and Metabolism : TEM·C F LimG Hennemann
Jun 12, 2002·Endocrinology and Metabolism Clinics of North America·Joanne E Langton, Gregory A Brent
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·L ChiovatoA Pinchera
Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·X P PangJ M Hershman
Dec 1, 1995·Thyroid : Official Journal of the American Thyroid Association·L A Burmeister
Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·J MagnerP Fletcher
Nov 25, 1998·Thyroid : Official Journal of the American Thyroid Association·L Persani
Apr 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A E PekaryJ M Hershman
Nov 1, 1994·Journal of Clinical Pathology·M L WellbyW E Roediger
Nov 1, 1995·Journal of the American Academy of Nurse Practitioners·P White
Jan 1, 1996·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·I J Chopra
Jul 1, 1993·Postgraduate Medicine·Todd B Kaye

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