Changes in thyrotropin-releasing hormone levels in hippocampal subregions induced by a model of human temporal lobe epilepsy: effect of partial and complete kindling

Neuroscience
S M Knoblach, M J Kubek

Abstract

Endogenous thyrotropin-releasing hormone has been hypothesized to modulate seizure activity, possibly by subserving an anticonvulsant function in limbic brain. A specific and sensitive radioimmunoassay was utilized to quantitate thyrotropin-releasing hormone levels in dorsoventrally dissected hippocampal subregions after partially (an experimental paradigm of complex partial epilepsy) or fully kindled (repeated generalized) seizures, to define specific seizure-related limbic pathways that may contain thyrotropin-releasing hormone. Samples were taken from electrode controls and 1, 6, 24, 48 and 144 h after a fully kindled seizure or 24 h after the first occurrence of a stage 3-4 (partially kindled) seizure in rats. Thyrotropin-releasing hormone levels were below controls in all subregions taken 1 h after a fully kindled seizure. They resembled control values 6 h after seizure, were substantially elevated at 24 and 48 h, and then returned to control levels by 144h. Low thyrotropin-releasing hormone levels seen shortly after the seizure presumably indicate peptide depletion during the ictus. The higher levels seen at later times occurred during a postictal period coinciding with refraction to additional seizure-generating stimulat...Continue Reading

References

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Citations

Jan 30, 2002·Pediatric Neurology·Michael J Kubek, Bhuwan P Garg
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Oct 24, 2007·Journal of Molecular Neuroscience : MN·Patricia de GortariPatricia Joseph-Bravo
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Oct 11, 2005·Neurochemistry International·P de GortariP Joseph-Bravo

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