PMID: 8586780Jun 1, 1995Paper

Changes in tissue calcium and phosphorus content and plasma concentrations of parathyroid hormone and calcitonin after long-term magnesium deficiency in rats

Journal of the American College of Nutrition
E PlanellsP Aranda

Abstract

The present study was undertaken to investigate the effect of dietary magnesium (Mg) deficiency on plasma levels of parathyroid hormone (PTH) and calcitonin (CT), and the changes in tissue calcium (Ca) and phosphorus (P) content. Wistar rats were fed an Mg-deficient diet. Plasma levels of PTH and CT, and Ca and P content in plasma, whole blood, skeletal muscle, heart, kidney, femoral bone and brain, were determined after 7, 35, 42, 49, 56, 63 and 70 days. Mg deficiency significantly increased plasma levels of ionic Ca after 1 week of deficiency, and significantly increased total Ca in plasma and whole blood after 5 weeks. Whole blood and plasma levels of P decreased significantly after 8 and 5 weeks, respectively, in comparison with values obtained in pair-fed control rats. Plasma levels of CT were not modified by hypercalcemia and hypomagnesemia. Plasma PTH decreased significantly during the first 3 weeks, then recovered gradually, reaching control values in week 7 and remaining stable thereafter, despite elevated levels of ionic Ca. The Mg-deficient diet led to calcification in skeletal muscle, heart, kidney and femur, detectable as early as week 5. However, P content increased only in kidney after 1 week, decreased in heart ...Continue Reading

References

Jun 1, 1978·Experimental and Molecular Pathology·G E Bunce, G A King
Jan 1, 1991·Annual Review of Physiology·Z S Agus, M Morad
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·S FatemiR K Rude
Jan 1, 1991·Annual Review of Physiology·P W Flatman
Jan 1, 1990·Annals of Nutrition & Metabolism·P ArandaG Urbano
Aug 1, 1989·The American Journal of Physiology·S TongyaiF W Heaton
Jun 1, 1988·The Journal of Nutrition·J J Welsh, V M Weaver
May 1, 1987·The American Journal of Clinical Nutrition·P O Wester
Jul 1, 1983·Endocrinology·C S Anast, L F Forte
Sep 18, 1980·The New England Journal of Medicine·D RudmanM H Kutner
Jan 1, 1993·Annals of Nutrition & Metabolism·A LermaJ Llopis
Mar 1, 1993·The American Journal of Physiology·D T Dransfield, J R Aprille

❮ Previous
Next ❯

Citations

Feb 24, 2001·Journal of Physiology and Biochemistry·E PlanellsJ Llopis
Mar 15, 2000·The Journal of Nutritional Biochemistry·N Sanchez-MoritoJ Llopis
Oct 8, 1999·Journal of the American College of Nutrition·N Sanchez-MoritoJ Llopis
Jul 14, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fatih KircelliJutta Passlick-Deetjen
May 23, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steven Van LaeckeRaymond Vanholder
Apr 24, 2015·International Journal of Molecular Sciences·Rachel NicollMichael Y Henein
Mar 20, 2014·Hemodialysis International·Periklis DousdampanisCostas Fourtounas
Jul 18, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lin LiKamyar Kalantar-Zadeh
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacob Atsmon, Eran Dolev
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Julia ThumfartDominik Müller
Apr 1, 1997·Journal of the American College of Nutrition·A JiménezJ Llopis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.