PMID: 9170476Jun 1, 1997Paper

Changes in total, CD4+, and CD8+ lymphocytes during pregnancy and 1 year postpartum in human immunodeficiency virus-infected women. The Women and Infants Transmission Study

Obstetrics and Gynecology
R TuomalaD N Burns

Abstract

To assess changes in lymphocyte subsets during pregnancy and 1 year postpartum in human immunodeficiency virus (HIV)-infected women. Changes in CD4+ and CD8+ cell counts, CD4 and CD8 percent, CD4/CD8 ratio, and total lymphocyte count and percent were assessed in each of 226 HIV-infected women followed during pregnancy and 1 year postpartum, and for each of 100 nonpregnant HIV-infected woman during 1 year. Trends over time were compared between pregnant women with and without several covariates. Postpartum changes over a 1-year period were compared to a 1-year period in the nonpregnant cohort. There was a mean increase of 2.76 per week in the CD4+ cell count during pregnancy (P = .04). No other characteristics changed significantly during pregnancy. The mean CD4+ and CD8+ cell counts, the CD8 percent, and the total lymphocyte count and percent increased immediately postdelivery. During the first postpartum year, there were statistically significant declines in the absolute CD4+ and CD8+ cell counts, the relative CD4 and CD8 percentages, and the total lymphocyte count and percentage. The rate of change for CD4+ and CD8+ counts, but not for CD4 percent, was less during 1 year in the nonpregnant cohort than in the first postpartum ...Continue Reading

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Citations

Apr 18, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A VimercatiL Selvaggi
May 29, 2003·Journal of Clinical Anesthesia·Krzysztof M Kuczkowski
Jun 14, 2002·The New England Journal of Medicine·D Heather Watts
Apr 20, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E KaplanH Watts
Apr 21, 2005·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Constance A BensonUNKNOWN Infectious Diseases Society of America
May 10, 2001·Clinical Obstetrics and Gynecology·L Ahdieh
Feb 12, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P StrattonH Minkoff
Apr 19, 2012·Clinical Obstetrics and Gynecology·John A Davis, Sigal Yawetz
May 30, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Risa M HoffmanJudith S Currier
May 5, 2007·BMJ : British Medical Journal·Glenda E Gray, James A McIntyre
Oct 14, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C M ChamaA Kayode
Mar 19, 2004·Revista do Hospital das Clínicas·Patrícia El BeituneErnesto Antônio Figueiró-Filho
Apr 7, 2017·American Journal of Reproductive Immunology : AJRI·Wilson L MandalaCalman A MacLennan
Apr 9, 2005·Clinical and Diagnostic Laboratory Immunology·Olumuyiwa AinaUNKNOWN Institute of Human Virology/Plateau State Specialist Hospital AIDS Prevention in Nigeria Study Team
Sep 11, 2004·Clinical and Diagnostic Laboratory Immunology·Hermann BussmannRichard Marlink
Sep 12, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amita GuptaUNKNOWN Byramji Jeejeebhoy Medical College-Johns Hopkins University Study Group

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