Changes in transepidermal water loss and skin hydration according to expression of aquaporin-3 in psoriasis.

Annals of Dermatology
Young LeeJeung Hoon Lee

Abstract

Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types. Among the AQPs, AQP3 is known to be a water/glycerol transporter expressed in human skin. The relationship between the expression level of AQP3 and transpidermal water loss (TEWL) in the lesional and peri-lesional skin of psoriasis-affected patients, and skin hydration in the lesional and peri-lesional skin of psoriasis patients, was investigated. The expression of AQP3 in psoriasis-affected and healthy control skin was determined using immunohistochemical and immunofluroscence staining. TEWL and skin hydration were measured using a Tewameter® TM210 (Courage & Khazaka, Cologne, Germany) and a Corneometer® CM 820 (Courage & Khazaka), respectively. AQP3 was mainly expressed in the plasma membrane of stratum corneum and the stratum spinosum in normal epidermis. Unlike the normal epidermis, AQP3 showed decreased expression in the lesional and peri-lesional epidermis of psoriasis. TEWL was increased, and skin hydration was decreased, in the lesional and peri-lesional skin of psoriasis patients, compared with the healthy control sample. Although various factors contribute to reduced skin hydration in the lesi...Continue Reading

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Citations

Jun 25, 2015·Ultrastructural Pathology·Iman SeleitEman Ragheb
Jul 1, 2014·International Journal of Pharmaceutics·Meera Gujjar, Ajay K Banga
Apr 18, 2015·Journal of Translational Medicine·Jian WangHongzhi Sun
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Mar 9, 2018·Cell Death & Disease·Graeme P SullivanSeamus J Martin
Oct 29, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Iman SeleitGehan Hamza
Apr 9, 2020·American Journal of Physiology. Cell Physiology·Wendy B BollagKelly A Hyndman
Oct 11, 2020·Indian Journal of Dermatology, Venereology and Leprology·Taraneh YazdanparastAlireza Firooz
Dec 31, 2020·Photodermatology, Photoimmunology & Photomedicine·Trinidad Montero-VilchezSalvador Arias-Santiago
Jan 27, 2021·Biomedicines·Nobutomo IkarashiJunzo Kamei
Feb 10, 2021·Journal of Cellular Physiology·Moein AlaAhmad Reza Dehpour
Apr 3, 2021·Frontiers in Genetics·Abul Kalam AzadParveen Afroz Chowdhury
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Jul 3, 2021·Healthcare·Nobutomo IkarashiJunzo Kamei
Nov 18, 2021·Experimental Dermatology·Liat SamuelovEli Sprecher

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Methods Mentioned

BETA
protein assay
immune blot
biopsies

Software Mentioned

SPSS

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