Changes in unstable coronary atherosclerotic plaque composition after balloon angioplasty as determined by analysis of intravascular ultrasound radiofrequency

The American Journal of Cardiology
Hu WeiJean-Pierre Bassand

Abstract

The effects of balloon angioplasty (BA) on plaque distribution remain incompletely documented. In 20 patients with unstable angina pectoris, intravascular ultrasound gray scale and radiofrequency analyses were performed before and after BA. Composition of the plaque was 61% fibrotic tissue, 15% fibrofatty tissue, 15% necrotic tissue, and 7% dense calcium tissue. After BA, 35% of lumen enlargement was due to an increase in total vessel area and 65% to a significant decrease in plaque area. This resulted from a longitudinal redistribution of the tissue toward the reference segments. Radiofrequency analysis showed that the fibrous and fibrofatty tissues were able to redistribute longitudinally, whereas calcium remained at the same level. A third of necrotic tissue was lost after BA. In conclusion, in unstable plaques, BA resulted in a longitudinal redistribution of fibrotic and fibrofatty tissues and disappearance of 1/3 of necrotic tissue.

References

Feb 15, 1996·The American Journal of Cardiology·G S MintzM B Leon
Nov 14, 2000·The American Journal of Cardiology·A MaeharaP J Fitzgerald
May 10, 2007·European Heart Journal·Andrew D FrutkinSteven P Marso

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Citations

Aug 14, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Somjot S BrarGregg W Stone
Jul 12, 2012·European Heart Journal Cardiovascular Imaging·Scott W MurrayNicholas D Palmer
Aug 14, 2010·JACC. Cardiovascular Imaging·James E MullerE Murat Tuzcu
Nov 4, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Patrick A CalvertMartin R Bennett
Dec 25, 2009·Circulation. Cardiovascular Interventions·Akiko MaeharaNeil J Weissman

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