PMID: 1199727Sep 1, 1975Paper

Changes in vascular permeability in stroke-prone spontaneously hypertensive rats studied with peroxidase as a tracer

Acta Pathologica Japonica
F HazamaK Okamoto

Abstract

Cerebrovascular permeability in stroke-prone spontaneously hypertensive rats (SHR) at various ages was histologically studied using horseradish peroxidase as a tracer and such was related to the cerebrovascular lesions in the animals. An increase in permeability was demonstrated in the brain of SHR, particularly in those animals with an extremely high blood pressure. Increased cerebrovascular permeability occurred in some animals without any organic vascular change or severe parenchymal changes, although edema was present. Histologically, the SHR brain with an increase in permeability showed mild focal edema, rarefaction of tissue and necrosis with cyst formation. Thus a transitional progress was evident. Localization of the increase in permeability corresponded well with the predilection sites of cerebrovascular lesions in SHR. Constrictions and dilatations of intracerebral arterioles and small arteries were also demonstrated by the peroxidase method, and the dilated arterial walls did reveal a darker staining. From these results it is strongly suggested that certain cerebrovascular lesions, especially necrosis with cyst formation in SHR are sequelae of the increased cerebrovascular permeability caused by a chronic hypertensiv...Continue Reading

References

Jun 1, 1975·Clinical Science and Molecular Medicine. Supplement·K OkamotoA Nagaoka
Nov 1, 1969·The Quarterly Journal of Experimental Psychology·G H Fisher
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI

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Citations

Jan 1, 1988·Acta Neuropathologica·K FredrikssonY Olsson
Jan 1, 1985·Acta Neuropathologica·K FredrikssonB B Johansson
Aug 1, 1988·Experimental and Molecular Pathology·N YukiokaF Hazama
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Midol-MonnetY Cohen
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·Y OlssonE Englund
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·K SuzukiM Takatama
Nov 1, 1980·Hypertension·S M Mueller, D D Heistad
Jan 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fanny HerissonCenk Ayata
Dec 1, 2007·Clinical Science·Jessica M OsmondAnne M Dorrance

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