Changes in vascular resistance in the umbilical and middle cerebral arteries in the human intrauterine growth-retarded fetus, measured with pulsed Doppler ultrasound

Early Human Development
S SatohH Nakano

Abstract

To assess how different cardiotocographic (CTG) findings are related to changes in vascular resistance, 256 normal and 37 growth retarded (IUGR) fetuses from 27 to 41 weeks of gestation were studied. Immediately following CTG monitoring, pulsed Doppler was used to identify flow velocity waveforms in both the middle cerebral artery (MCA) and the umbilical artery (UA), and from these the Resistance Indices (RIs) in both arteries (RIMCA and RIUA) were calculated. Of the 37 growth retarded fetuses, 25 had normal CTG findings. Although only 3 (12.0%) of these fetuses had low RIMCA, 12 (48.0%) had high RIUA, statistically different (P less than 0.01) from normal fetuses. In 11 of 12 (91.7%) growth retarded fetuses with an abnormal CTG, there were low RIMCA values, significantly more (P less than 0.01) than in those with a normal CTG. As for RIUA, all 12 IUGR fetuses with an abnormal CTG had high RIUA values (100%), a much higher proportion (P less than 0.01) than was found in the normal CTG group. These results mean that intrauterine fetal growth retardation per se is associated with a chronic increase in the RI value in the umbilical artery. By contrast, cerebral vascular resistance appears to decrease in compromised conditions, as ...Continue Reading

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Citations

Mar 6, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R RomeroN Kadar
Jan 1, 1994·Journal of Perinatal Medicine
Sep 1, 2009·Journal of Medical Ultrasonics·Toshiyuki Yoshizato, Shoji Satoh
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Mar 1, 2011·Clinics in Perinatology·Mauro H Schenone, Giancarlo Mari
Jan 14, 2011·Placenta·M Wareing, S L Greenwood
May 29, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mark Wareing
Nov 5, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·N WadaK Hecher
Jun 13, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yasushi KuriharaMasayasu Koyama

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