Changes in VIP-, SP- and CGRP- like immunoreactivity in intramural neurons within the pig stomach following supplementation with low and high doses of acrylamide

Neurotoxicology
Katarzyna PalusJarosław Całka

Abstract

Acrylamide is one of the food toxins to which the human body is exposed. Although researchers' interest in acrylamide has been growing in recent years, the knowledge of its effect on the gastrointestinal tract, especially on intramural neurons which form the enteric nervous system is scarce. The aim of this experiment was to determine the influence of acrylamide, administered at doses equivalent to the human tolerable daily intake (TDI, 0.5 μg/kg b.w./day) and ten times higher than the TDI (5 μg/kg b.w./day), on the distribution of vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene related peptide (CGRP) in intramural neurons of the domestic pig stomach. Using double immunofluorescent labelling we revealed that the ENS neurons underwent adaptive changes in response to the supplementation of acrylamide, which manifested themselves as increased expression of VIP, SP and CGRP, both in intramural neurons and by an increase in the nerve density in submucous and muscular layers in the porcine stomach. These substances take part in defensive reactions of neurons and transmission of sensory reactions may play an important role in protecting the stomach against the harmful effect of acrylamide. Moreover, it has b...Continue Reading

Citations

Jul 11, 2019·International Journal of Molecular Sciences·Katarzyna PalusJarosław Całka
Apr 17, 2019·International Journal of Molecular Sciences·Michał BulcJarosław Całka
Oct 6, 2020·Frontiers in Pharmacology·Marta Czajkowska, Jarosław Całka
Jul 8, 2020·International Journal of Molecular Sciences·Slawomir Gonkowski
Jan 10, 2021·Animals : an Open Access Journal From MDPI·Krystyna Makowska, Sławomir Gonkowski
Jun 11, 2021·Scientific Reports·Krystyna MakowskaSlawomir Gonkowski

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