Changes in von Willebrand factor level and von Willebrand activity with age in type 1 von Willebrand disease

Haemophilia : the Official Journal of the World Federation of Hemophilia
N RydzPaula D James

Abstract

In a normal population, VWF plasma levels (VWF:Ag) and VWF activity (VWF:RCo) increase by approximately 0.17 and 0.15 IU mL(-1) per decade, but the influence of age is unknown in patients with type 1 von Willebrand disease (VWD). In a retrospective cohort study, the medical records of 31 type 1 VWD patients over the age of 30, who had been followed for ≥5 years, were reviewed for baseline clinical data and previously performed VWF:Ag, VWF:RCo and factor VIII levels ( C). VWF multimer analysis was normal in 28/31 cases performed. Mean age at diagnosis was 33 (range 16-60 years), and duration of follow-up ranged from 5 to 26 years (mean 11 years). Patients had 2-10 time points of VWD testing (mean of 5.2). The mean VWF:Ag, VWF:RCo and C at time of diagnosis were 0.44 IU mL(-1) 0.34 IU mL(-1) and 0.75 IU mL(-1) . At last follow-up, the mean VWF:Ag, VWF:RCo and C were significantly increased to 0.71 IU L(-1) , 0.56 IU mL(-1) and 0.90 IU mL(-1) (P ≤ 0.001, <0.001, and 0.0081 respectively). Here 18/31 patients had VWF:Ag, VWF:RCo and C levels that increased into the normal range. The rate of change in VWF:Ag, VWF:RCo and FVIII was 0.30 IU mL(-1) (0.21-0.39, CI 95%, P < 0.0001), 0.20 IU mL(-1) per decade (0.13-0.27, CI 95%, P = 0.0001...Continue Reading

References

Nov 1, 1989·Archives of Gerontology and Geriatrics·K HagerD Platt
Sep 4, 1987·JAMA : the Journal of the American Medical Association·W B KannelR B D'Agostino
Apr 1, 1994·British Journal of Haematology·G DolanF E Preston
May 1, 1996·Age and Ageing·R W StoutT C Morris
May 8, 2000·Journal of Applied Physiology·P J van den BurgI A Huisveld
May 16, 2003·American Journal of Hematology·Ronald D BarrIrwin Walker
Sep 2, 2003·Pathologie-biologie·Cécile V Denis
Jul 18, 2006·Journal of Science and Medicine in Sport·J RibeiroJ Duarte
Jul 25, 2006·Critical Reviews in Oncology/hematology·Massimo Franchini
Sep 18, 2007·Experimental Gerontology·Daniela MariRita Provenzano
Feb 19, 2008·Thrombosis and Haemostasis·Cécile V DenisPeter J Lenting
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·M BowmanP James
May 29, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·W MiesbachE Seifried
Jun 6, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·W MiesbachE Seifried
Mar 30, 2010·Journal of Thrombosis and Haemostasis : JTH·E M de WeeUNKNOWN Win Study Group
May 4, 2011·Journal of Thrombosis and Haemostasis : JTH·K KokameT Miyata

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Citations

Dec 30, 2015·Journal of Thrombosis and Haemostasis : JTH·A de Jong, J Eikenboom
Feb 16, 2016·Journal of Thrombosis and Haemostasis : JTH·S AlbánezD Lillicrap
Jun 14, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·V DaidoneA Casonato
Jul 19, 2016·Current Opinion in Hematology·Laura L Swystun, David Lillicrap
Dec 4, 2016·Hematology·Michelle Lavin, James S O'Donnell
Sep 7, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Craig D Seaman, Margaret V Ragni
Sep 23, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mariya H ApostolovaMargaret V Ragni
Sep 25, 2018·Journal of Thrombosis and Haemostasis : JTH·L L Swystun, D Lillicrap
Nov 4, 2017·American Journal of Hematology·Mouhamed Yazan Abou-IsmailPeter A Kouides
May 13, 2020·British Journal of Haematology·Helen FogartyJames S O'Donnell
Jul 7, 2020·Thrombosis and Haemostasis·Craig D Seaman, Margaret V Ragni
Jun 8, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·F W G Leebeek, S Susen
Dec 14, 2016·The New England Journal of Medicine·Frank W G Leebeek, Jeroen C J Eikenboom
Nov 18, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·M Laffan
Dec 7, 2019·Hematology·James S O'Donnell, Michelle Lavin
Oct 1, 2020·Journal of Thrombosis and Haemostasis : JTH·Eugenia BiguzziFlora Peyvandi
Nov 23, 2020·Thrombosis Research·Eugenia BiguzziAstrid van Hylckama Vlieg
Feb 4, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Megan E SampsonJohn H Fargo
Feb 12, 2021·Blood Advances·Paula D JamesReem A Mustafa
Mar 30, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·John Michael SouciePeter A Kouides
Mar 3, 2021·European Journal of Haematology·Cedric HermansK John Pasi
Dec 11, 2021·Hematology·Mouhamed Yazan Abou-Ismail, Nathan T Connell

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