PMID: 15374463Jan 1, 1991Paper

Changes in water solubility of proteins in aging rat brain

Archives of Gerontology and Geriatrics
Z KristofikováH Tejkalová

Abstract

Changes in the water solubility of proteins in the brain tissue of Wistar rats were investigated: (i) during aging (in 3-32 month animals) and (ii) 24 h after killing 3 month animals. The protein concentration was determined by the method of Lowry. In both cases we observed a considerable difference in the protein solubility, i.e., that the ratio of water-soluble to water-insoluble proteins changed. A change of protein solubility was largest in the brain regions especially sensitive to the oxygen supply (hippocampus, striatum, hypothalamus and cortex) and is statistically significant already in 14 month animals.

References

Jan 1, 1979·Experimental Gerontology·D NaberK Krack
Nov 21, 1978·Journal of Theoretical Biology·I Zs-Nagy
Sep 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·L G FeldJ B Van Liew
Jan 1, 1980·Annals of the New York Academy of Sciences·A L Tappel
Jan 1, 1982·Experimental Brain Research·I Z NagyG Lustyik
Jul 1, 1956·Journal of Gerontology·D HARMAN
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G J BoerH B Uylings

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