Changes in White Matter Microstructure Suggest an Inflammatory Origin of Neuropsychiatric Systemic Lupus Erythematosus

Arthritis & Rheumatology
César Magro-ChecaG M Steup-Beekman

Abstract

To assess white matter (WM) and gray matter (GM) magnetization transfer ratio histogram peak heights (MTR-HPHs) in different subsets of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) who have unremarkable findings on 3T magnetic resonance imaging of the brain and to evaluate whether these values could be used to highlight different clinically suspected underlying pathogenic processes or identify the clinical NPSLE status or whether they could be associated with a specific NPSLE syndrome. Sixty-four SLE patients with neuropsychiatric symptoms were included. The initial NPSLE diagnosis and suspected underlying pathogenic process were established by multidisciplinary evaluation. The final diagnosis was made after also considering the disease course 6-18 months later. Thirty-three patients with central nervous system (CNS) NPSLE and 31 SLE patients with neuropsychiatric symptoms unrelated to SLE (non-SLE-related NP) were included. Twenty SLE patients without neuropsychiatric symptoms and 36 healthy control subjects were included for comparison. Differences in the WM and GM mean MTR-HPHs and between the different NPSLE subgroups (CNS NPSLE diagnosis, NPSLE phenotype [inflammatory or ischemic], and clinical chang...Continue Reading

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Citations

Jun 22, 2018·Arthritis & Rheumatology·John G HanlyJulius Birnbaum
Oct 23, 2018·Arthritis & Rheumatology·Michael D Lockshin
Aug 16, 2019·Current Opinion in Rheumatology·Dionysis NikolopoulosDimitrios T Boumpas
Apr 12, 2019·Frontiers in Medicine·Antonis FanouriakisMarcello Govoni
Dec 11, 2020·Computational and Mathematical Methods in Medicine·Yan LiRenhua Wu
Dec 29, 2020·Rheumatology·Giuseppe A RamirezMassimo Filippi
Mar 9, 2021·Expert Review of Clinical Immunology·Dionysis NikolopoulosGeorge Bertsias

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