Changes induced by chronic in vivo load alteration in the tibiofemoral joint of mature rabbits.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Maria RoemhildtCalsey Grant

Abstract

We investigated the relationship between the magnitude and duration of chronic compressive load alteration and the development and progression of degenerative changes in the rabbit tibiofemoral joint. Varus loading devices were attached to the hind limb of mature NZW rabbits. Altered compressive loads of 0%, 50%, and 80% body weight (BW) were applied to the tibiofemoral joint for 12 h per day for 12 and 24 weeks (n = 4 animals/group). Compartment-specific assessment of the tibial plateau included histological assessments (articular cartilage, calcified cartilage, and subchondral bone thicknesses, degeneration score, and articular cartilage cellularity) and biomechanical measures (aggregate modulus, permeability, Poisson's ratio). Analyses of variance techniques were used to examine the relationship between each outcome measure with load magnitude and duration as independent variables in the model. Degenerative changes developed in the medial compartment with increased magnitude of compressive loading and included fibrillation, increased degeneration score, and reduced cellularity of the articular cartilage. Increased calcified cartilage thickness was observed in both the medial and lateral compartments following exposure to alt...Continue Reading

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Citations

Apr 7, 2012·The Orthopedic Clinics of North America·Harpal K Gahunia, Kenneth P H Pritzker
Feb 19, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Juha-Pekka KulmalaJanne Avela
Nov 6, 2012·Osteoarthritis and Cartilage·M L RoemhildtG J Badger
Oct 1, 2013·Journal of Biomechanics·Pauline GerusDavid G Lloyd
May 31, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A HolzerG Holzer
Jun 7, 2017·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Haoliuyang CaiLingying Tong

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