PMID: 9555974Apr 29, 1998Paper

Changes of amino acid levels and aspartate distribution in the cervical spinal cord after traumatic spinal cord injury

Journal of Neurotrauma
M WatanabeY Ogawa

Abstract

To evaluate the role of excitatory amino acids in secondary injury occurring after spinal cord trauma, several experimental studies focusing on the the changes of amino acid levels in the spinal cord have been performed to date. However, because of technical limitations, it has not been possible to correlate the local changes of excitatory amino acids with the total tissue levels of excitatory amino acids. To investigate the connection between the spread of injury and the excitatory amino acids, we assessed, the local changes of aspartate through novel experimental approaches like immunoreactivity via fluorescence microphotometry and histopathology while also analyzing the total tissue levels of amino acids via HPLC. These studies were performed using a model of incomplete cervical spinal cord injury in rats. Through this approach, we found that the levels of excitatory amino acids, such as glutamate and aspartate, began to decrease immediately after injury. No significant decrease was observed in the other amino acids. Similarly, local changes in aspartate in the spinal cord were observed using fluorescence microphotometry. The decrease in the anterior and posterior horns was rapid up to 15 min after injury, but, slowed therea...Continue Reading

References

Nov 8, 1990·Brain Research·R J UlshaferD R Wallace
Jan 1, 1990·Annals of Neurology·S S PanterA I Faden
Jun 1, 1988·Annals of Neurology·A I Faden, R P Simon
Sep 1, 1980·Journal of Neurosurgery·D K AndersonC J Spears

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Citations

Sep 11, 2001·Journal of Neuroscience Research·K IshiiK Uyemura
May 25, 2011·Pharmacology & Therapeutics·Alexander G RabchevskyJoe E Springer
Jul 31, 2004·Brain Research. Developmental Brain Research·Kwame M BrownBarry B Wolfe
Jun 7, 2014·The European Journal of Neuroscience·Masahiro KuroiwaJoji Mochida
Dec 31, 1998·Current Opinion in Neurology·M Giménez y Ribotta, A Privat
Oct 30, 2012·International Surgery·F J Pérez LaraH Oliva Muñoz

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