Changes of angiogenin serum concentrations in the perinatal period

Pediatric Research
A Malamitsi-PuchnerI Phocas

Abstract

The polypeptide angiogenin, a normal constituent of human plasma, might be involved in endothelium homeostasis, angiogenesis, and neovascularization accompanying various diseases. This study aimed at determining angiogenin serum concentrations in the perinatal period of healthy newborns and at forming a baseline for this protein, which in the future may serve as a diagnostic index in developmental errors of the placenta and/or newborn. One milliliter of blood was drawn on d 1 and 4 of life from 30 healthy full-term neonates, and angiogenin serum concentrations were measured by an enzyme immunoassay using a commercially available kit. In 10 cases angiogenin serum concentrations were also measured in the maternal serum before delivery and in the umbilical vein serum. Angiogenin serum concentrations (microgram/L) were significantly higher in maternal serum (225.7 +/- 49.6) compared with umbilical vein serum (119.0 +/- 34.2) (p < 0.0002), as well as that compared with day 1 (166.4 +/- 44.9) (p < 0.01) but not to d 4 neonatal serum (240.8 +/- 52.6). Angiogenin serum concentrations showed a statistically significant increase from d 1 to 4 (p < 10(-7)), as well as from umbilical cord serum to d 1 neonatal serum (p < 0.0002). A statist...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Soncin
Jun 17, 1986·Biochemistry·R ShapiroB L Vallee
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Jun 1, 1988·British Journal of Cancer·J F Riordan, B L Vallee
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R Bicknell, B L Vallee
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W F HeathB L Vallee
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R Bicknell, B L Vallee
May 30, 1989·Biochemical and Biophysical Research Communications·F S Lee, B L Vallee
Sep 24, 1985·Biochemistry·D J StrydomB L Vallee
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R ShapiroB L Vallee
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Shapiro, B L Vallee
Aug 14, 1987·Biochemical and Biophysical Research Communications·S M RybakB L Vallee
Aug 11, 1987·Biochemistry·R ShapiroB L Vallee
Apr 1, 1984·British Journal of Cancer·B Hobson, J Denekamp
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·V NobileR Shapiro

❮ Previous
Next ❯

Citations

Jan 12, 1999·Mediators of Inflammation·A SarandakouI Phocas
Jun 11, 1998·Pediatric Research·A Malamitsi-PuchnerC S Bartsocas
Aug 6, 2014·BioMed Research International·Nadine PavlovJosette Badet
Sep 25, 1999·Growth Factors·A Malamitsi-PuchnerG Creatsas
Jul 1, 2011·Pregnancy Hypertension·Vellore J KarthikeyanAndrew D Blann
Dec 26, 2015·Acta Biochimica Et Biophysica Sinica·Jinghao Sheng, Zhengping Xu
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·A Tello-MontoliuG Y H Lip

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.