Jan 1, 1989

Changes of basal and steroidal precursor-stimulated testosterone secretion in isolated Mongolian gerbil and guinea pig testes after a single episode of heating

Comparative Biochemistry and Physiology. A, Comparative Physiology
M Fenske

Abstract

1. In the absence of steroidal precursors, testosterone secretion by Mongolian gerbil testes incubated at 37 degrees C was 340 ng/g tissue/4 hr. Addition of 1 microgram progesterone or DHEA drastically stimulated testosterone secretion by testes incubated at 37 degrees C (progesterone: 3281 ng/g tissue/4 hr, DHEA: 4654 ng/g tissue/4 hr). 2. While neither basal nor DHEA-stimulated production of testosterone was significantly affected by a single episode of heating (43-44 C for 30 min), progesterone-stimulated testosterone secretion markedly decreased during the 4-hr incubation period. 3. In contrast, in isolated testes of adult guinea pigs, a single episode of heating (44 degrees C for 30 min) resulted in a drastic reduction of basal and precursor-stimulated testosterone production during the 4-hr incubation period. 4. From these data it appears that enzymatic activities in the testes of the two species do not have their maxima at the same temperature, but rather in each case at, or close to, the temperature prevailing in the scrotal testis.

  • References25
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Psammomys
Testosterone Measurement
Benign Neoplasm of Testis
Scrotum
Progesterone, (9 beta,10 alpha)-Isomer
Neoplasm of Uncertain or Unknown Behavior of Testis
Cavia
Testolin
Hot Temperature
Progesterone

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.