PMID: 7529081Sep 1, 1994Paper

Changes of blood CD16/CD56 (NK) and HLA-DR/CD3-positive lymphocyte amounts in HIV-infected children, as related to clinical progression and p24-antigen/p24-antibody presence

FEMS Immunology and Medical Microbiology
C L VoiculescuE Radu

Abstract

This study describes a series of immunological investigations carried out on a group of 37 HIV-seropositive children, aged 3-4 years, in two different stages of disease defined according to the CDC classification; the Primary stage, an asymptomatic one, showing abnormal immune function (P1-Class, B-Subclass) and the Secondary stage, 6-8 months later, in which patients exhibited non-specific findings, i.e., loss of weight, persistent generalized lymphadenopathy and hepatosplenomegaly, associated with abnormal immune function (P2-Class, A-Subclass). In both stages, immune function was considered 'abnormal' when lymphopenia and a decrease of the CD4/CD8-cell ratio were found. The phenotypes CD16+/56+ (NK) and HLA-DR+/CD3+ (T-activated?)-positive cells, were assessed by flow cytometry, and the following supplementary systemic humoral markers were investigated in homologus serum samples; total HIV(gp)-antibody, HIV(p24)-antibody and p24-antigen presence. If at the primary stage, no significant difference from to the reference values corresponding to the age was noticed, at the Secondary stage the obtained data is presented separately in two subgroups, namely the A-subgroup characterized by the presence of total HIV(gp)-antibody, the...Continue Reading

References

Mar 1, 1991·The Pediatric Infectious Disease Journal·Z F Rosenberg, A S Fauci
Feb 1, 1992·The Journal of Pediatrics·F M Erkeller-YukselF Vanlangendonck
Jan 9, 1986·The New England Journal of Medicine·R R RedfieldE C Tramont
Jun 1, 1988·The Pediatric Infectious Disease Journal·N KamaniL R Krilov
Nov 1, 1986·Pediatric Research·Y YanaseT Kawasaki

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