Dec 1, 1989

Changes of blood flow in the adenohypophysis of normal and estrogen pretreated Fisher rats by tamoxifen

Acta Endocrinologica
A StawowyJ Jakubowski


Blood flow was measured in the adenohypophysis and in the cerebral cortex of female F344 rats over a period of 90 min using the hydrogen clearance method. Tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. Seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. Anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing implants. These rats responded to 7 days of sc tamoxifen treatment by 30% increase in adenohypophyseal blood flow. These results suggest that tamoxifen has a different effect on adenohypophysial circulation of the rat depending on whether it is administered in a low- or high-estrogen state.

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Mentioned in this Paper

Arterial Pulse Pressure
Cerebral Blood Flow Imaging
Subcutaneous Injections
Pituitary Diseases
Regional Blood Flow
Blood Flow
Rats, Inbred F344
Pituitary Gland, Anterior
Cerebrovascular Circulation

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