Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats

Life Sciences
Takayuki IshiwataYasutsugu Aihara

Abstract

Although many studies has been shown that serotonin (5-HT) in the preoptic area and anterior hypothalamus (PO/AH) is important for regulating body temperature (Tb), the exact role is not established yet due to conflicting results probably related to experimental techniques or conditions such as the use of anesthesia. The purpose of present study was to clarify the role of 5-HT in the PO/AH using the combined methods of telemetry, microdialysis and high performance liquid chromatography (HPLC), with a special emphasis on the regulation of Tb in freely moving rats. Firstly, we measured changes in Tb and levels of extracellular 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the PO/AH during cold (5 degrees C) and heat (35 degrees C) exposure. We also perfused fluoxetine (5-HT re-uptake inhibitor) and 8-hydroxy-2-(Di-n-propylamino)tetralin (8-OH-DPAT: 5-HT1A agonist) into the PO/AH. During both exposures, although Tb changed significantly, no significant changes were noted in extracellular levels of 5-HT and 5-HIAA in the PO/AH. In addition, although perfusion of fluoxetine or 8-OH-DPAT into the PO/AH increased or decreased extracellular 5-HT and 5-HIAA levels in the PO/AH respectively, but Tb did not change at all....Continue Reading

References

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Citations

Sep 29, 2015·Stress : the International Journal on the Biology of Stress·Reka NatarajanBryan K Yamamoto
Nov 5, 2010·Scandinavian Journal of Medicine & Science in Sports·R Meeusen, B Roelands
May 10, 2016·Journal of Thermal Biology·Hikaru NakagawaTakayuki Ishiwata
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Jul 20, 2018·International Journal of Environmental Research and Public Health·Mare Lõhmus
May 28, 2005·Journal of Applied Physiology·Hiroshi HasegawaYvette Michotte
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Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris
Aug 24, 2021·Journal of Thermal Biology·Hikaru Nakagawa, Takayuki Ishiwata

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