Changes of Bone Turnover Markers and Bone Tissue Content After Severe Osteoporotic Vertebral Compression Fracture.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Haoran QiGuodong Wang

Abstract

BACKGROUND The incidence of osteoporotic vertebral fractures (OVCFs) has increased significantly in recent years. In order to assess osteoporotic fracture healing process, it is necessary to study the characteristics after this type of vertebral fracture. However, there are few researches on fracture healing process in severe OVCFs. We aim to investigate the histological healing process and the kinetics of bone turnover markers following severe OVCFs. MATERIAL AND METHODS There were 149 patients with severe OVCFs included in this study. Fasting blood samples were obtained to detect bone turnover markers levels. A transpedicular bone biopsy was performed to collect bone biopsy specimens during vertebroplasty surgery. Stratification of healing process was performed: stage I (1-3 days), stage II (4-10 days), stage III (11-20 days), stage IV (21-30 days), stage V (1-3 months), stage VI (3-6 months). RESULTS Quantitative analysis of bone histomorphometry showed that a large amount of necrotic bone tissue was observed in stage VI (12.92±3.66%). Bone turnover markers showed the concentration of ß-isomerized C-terminal telopeptide (ß-CTX) which reflects activity in osteoclast continued to increase in stage VI (0.9±0.33 ng/mL). These re...Continue Reading

Citations

Dec 17, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Haoran QiGuodong Wang
Oct 15, 2021·The Journal of Bone and Joint Surgery. American Volume·Tamara D RozentalMary L Bouxsein
Jan 18, 2022·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Haoran QiGuodong Wang

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Methods Mentioned

BETA
x-ray
biopsy
light microscopy
biopsies

Software Mentioned

SPSS
Image Pro Plus Pro Plus

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