Changes of CD4+CD25+FOXP3+ and CD8+CD28- regulatory T cells in non-small cell lung cancer patients undergoing surgery

International Immunopharmacology
Cheng ChenHanbo Le

Abstract

Little is known about the regulatory T cells (Tregs) in the peripheral blood after surgery of non-small cell lung cancer (NSCLC) patients. In this study, we investigated whether CD4+CD25+FOXP3+ and CD8+CD28- regulatory T cells are decreased in the peripheral blood of NSCLC patients undergoing surgery. The study group (n = 49) comprised NSCLC, and the control group (n = 24) consisted of age- and sex-matched nonmalignant diseases. The prevalence of CD4+CD25+FOXP3+ and CD8+CD28- Tregs was analyzed using flow cytometry. The study group showed significantly higher percentage of CD4+CD25+FOXP3+ and CD8+CD28- Tregs than control. The percentage of CD4+CD25+FOXP3+ and CD8+CD28- Tregs increased with tumor stage. One way ANOVA test shows the significant differences between all subgroups. LSD test shows that there was a statistical significance between each of the two subgroups except stage II in CD4+CD25+FOXP3+ Tregs and control vs. each stage, stage I vs. stage III, and stage IV in CD8+CD28- Tregs. There is no significant difference among stages II, III, and IV in CD8+CD28- Tregs. No differences were found between squamous carcinoma and adenocarcinoma. These levels were dropped significantly after operation. Furthermore postoperative Tre...Continue Reading

References

Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 27, 2003·Nature Reviews. Immunology·Jeffrey A Bluestone, Abul K Abbas
Oct 3, 2003·The Journal of Clinical Investigation·Nader NajafianSamia J Khoury
Nov 12, 2003·Cancer Immunology, Immunotherapy : CII·Wei-Zen WeiYi-Chi M Kong
Nov 25, 2003·Current Opinion in Immunology·Marc Gavin, Alexander Rudensky
Mar 17, 2004·Current Opinion in Immunology·Masaki Terabe, Jay A Berzofsky
Mar 1, 2005·The Journal of Surgical Research·Hiromichi KawaidaHideki Fujii
Dec 6, 2005·Cancer Immunology, Immunotherapy : CII·Koji KonoHideki Fujii
Jul 25, 2006·Blood·Marc Beyer, Joachim L Schultze
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Massimiliano M CorsiLorenzo Pignataro
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
Apr 29, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rikiya NakamuraMasaru Miyazaki
Jun 23, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W Y KimC-W Kim
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Jan 13, 2010·Immunological Investigations·Valentina K TodorovaAnastas Pashov
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Aug 6, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alan SandlerDavid H Johnson
Mar 5, 2011·International Journal of Hematology·Tomonori YaguchiYutaka Kawakami
Feb 16, 2013·Surgery Today·Yu SaitoMichihito Asanoma

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Citations

Mar 20, 2016·International Immunopharmacology·Xin ChenZhiMing Huang
Jul 15, 2015·Cellular & Molecular Immunology·Shuping ZhangShiyang Pan
Dec 16, 2016·Scientific Reports·Athanasios KotsakisEleni-Kyriaki Vetsika
Feb 9, 2017·Frontiers in Immunology·Yirajen Vuddamalay, Joost P M van Meerwijk
Apr 21, 2018·Annals of the American Thoracic Society·Karl T Kelsey, John K Wiencke
Mar 6, 2018·Cellular & Molecular Immunology·Shuping ZhangFang Wang
Jan 5, 2020·International Journal of Cancer. Journal International Du Cancer·Jiabo DiXiangqian Su
Mar 2, 2018·AIDS·Isabelle Poizot-MartinFrançoise Dignat-George
Mar 3, 2020·The Journal of Clinical Investigation·Xia LiuGuangyong Peng
Oct 1, 2016·Oncotarget·María Del Mar Valenzuela-MembrivesMaría Esther Fárez-Vidal
Apr 9, 2019·Journal of Leukocyte Biology·Hai ZhaoLiangxue Zhou
Feb 18, 2017·World Journal of Gastroenterology : WJG·Wu ZhongFeng Gao
Dec 21, 2018·Frontiers in Oncology·John LynesEdjah Nduom
Jun 12, 2019·International Journal of Molecular Sciences·Wei X HuffMahua Dey
May 11, 2017·Journal of Neuroscience Research·Samuel S DuffyGila Moalem-Taylor
Dec 10, 2020·Journal for Immunotherapy of Cancer·Carolina TiraboschiDaniel Compagno
Apr 29, 2021·ImmunoTargets and Therapy·Yang YangXin Chen

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