Changes of cytokeratin and involucrin expression in squamous cell carcinomas of the skin during progression to malignancy

The British Journal of Dermatology
S WatanabeF Otsuka

Abstract

The detection of cytokeratins in neoplastic tissues by immunohistochemical methods has numerous diagnostic and investigative applications, because cytokeratins are usually conserved in tumour cells during malignant transformation. Recently, however, it has been reported that progression to malignancy is associated with commencement of expression of low-molecular-weight cytokeratins. In the present study, 42 specimens from 35 cases of squamous cell carcinoma (SCC) of the skin were analysed by immunohistochemical techniques, using polyclonal anti-involucrin antibody and a panel of monoclonal antikeratin antibodies, in order to investigate the nature and differentiation of SCCs. The expression of cytokeratins and involucrin in well-differentiated SCCs was similar to that in normal epidermis. In contrast with well-differentiated SCCs, the expression of differentiation-specific cytokeratins and involucrin was diminished in the immature tumour cells in proportion to the malignancy of the SCCs. Some antibodies, however, stained all tumour cells, irrespective of the degree of malignancy. Furthermore, expression of simple epithelial and non-cornifying stratified squamous epithelial cytokeratins was observed in atypical tumour cells of p...Continue Reading

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Citations

Jan 7, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·B H ShearerH F Jenkinson
Oct 3, 2002·The American Journal of Dermatopathology·Takamitsu OhnishiShinichi Watanabe
Mar 18, 2004·The Biochemical Journal·Nhu Q Tran, David L Crowe
Sep 25, 2012·Clinical and Experimental Dermatology·N ScolaT Gambichler
Apr 16, 2016·Annals of Dermatology·Jung-Min ShinYoung Lee
Dec 24, 1997·Journal of Cutaneous Pathology·E IchikawaS Watanabe
Jun 20, 2007·Experimental Dermatology·Baki AkgülAlan Storey
Jun 24, 2017·The Australasian Journal of Dermatology·Ryoko KimuraOsamu Yamamoto
Mar 4, 2017·The Journal of Dermatology·Shin-Ichi Ansai
May 10, 2018·The American Journal of Dermatopathology·Takeshi NamikiShin-Ichi Ansai
Apr 22, 2020·Life Science Alliance·Marco GualandiOlga Shakhova
Oct 11, 2013·Molecular Cancer Research : MCR·Hongyan ChenZhihua Liu
Aug 12, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R HuD Lau

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